Results 51 to 60 of about 23,598 (268)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj   +1 more source

Data of transcriptional effects of the merbarone-mediated inhibition of TOP2

Data in Brief, 2022
Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves, Pedro Manuel Martínez-García, Andrés Herrero-Ruiz, Francisco Gómez-Vela, Federico Divina, Silvia Jimeno-González, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source

“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]

, 2014
The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova, Baumann, Baxter, Baxter, Baxter, Bermejo, Bester, Branzei, Branzei, Brill, Burrell, Bzymek, Cejka, Champoux, Champoux, Chan, Chan, Chang, Chu, Crisona, Cuylen, Cuylen, Delbrück, Di Micco, Dominguez-Sola, Ekholm-Reed, Farcas, Fernandez, Gandhi, Gangloff, Gerlich, Germann, Giet, Goodwin, Gorgoulis, Halazonetis, Hardy, Hawkins, Hendzel, Hiasa, Hiasa, Hiasa, Hills, Hirano, Hirano, Hirano, Holm, Hsu, Jonathan Baxter, Kato, Kato, Khodursky, Khodursky, Kimura, Kimura, Kitamura, Koshland, Kreuzer, Kueng, Lavoie, Leman, Lucas, Mantiero, Maresca, Marston, Martinez-Robles, Matos, McClendon, McClintock, McGlynn, McGuffee, Mullen, Naughton, Neelsen, Newport, Oliveira, Ono, Paulson, Peter, Postow, Rattner, Rybenkov, Rybenkov, Sakaguchi, Samejima, Schoeffler, Schvartzman, Shamu, Shintomi, Spruck, Stuchinskaya, Sullivan, Sundin, Sundin, Suski, Symington, Szakal, Tedeschi, Temime-Smaali, Toledo, Vologodskii, Vos, Wang, Wang, Wang, Watson, Watson, Wei, Wilkins, Zechiedrich, Zechiedrich   +110 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle

Computational and Structural Biotechnology Journal, 2023
Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription.
Matic Pavlin, Barbara Herlah, Katja Valjavec, Andrej Perdih   +3 more
doaj   +1 more source

Transcriptional regulation of human topoisomerase II beta : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2006
Pages 24 and 25 are missing from the original copy.Topoisomerase II has an essential role in maintaining the DNA in the correct topological state required for various cellular processes.
Mawson, Claire
core  

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Stimuli‐Responsive Silsesquioxane Nanozymes for Organocatalysis in Water and Prodrug Activation in Cells

Angewandte Chemie, EarlyView.
Amino‐bearing silsesquioxanes are water‐stable nanozymes that exhibit aggregation‐ and disaggregation‐dependent catalysis and can be applied to intracellular prodrug activation for cancer therapy. ABSTRACT Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited ...
Rabia Zahid, Ariadna Lázaro, Guillermo Moreno‐Alcántar, María Sancho‐Albero, Pierre Picchetti   +4 more
wiley   +2 more sources

Anti-topoisomerase drugs as potent inducers of chromosomal aberrations

Genetics and Molecular Biology, 2000
DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs.
Loredana Bassi, Fabrizio Palitti
doaj   +1 more source