Results 21 to 30 of about 16,235 (248)

SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases

Frontiers in Molecular Biosciences, 2022
Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA.
Yilun Sun, John L. Nitiss, Yves Pommier
doaj   +1 more source

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases [PDF]

, 2010
ype II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage complex with a gate-DNA duplex that allows transport of a ...
Laponogov, I, Fisher L. Mark, Pan, Xiao-Su, Sanderson, MR, Xiao-Su Pan, Katherine E McAuley, Fisher, LM, McAuley, Katherine E., McAuley, KE, Pan Xiao-Su, Veselkov, Dennis A., Ivan Laponogov, Mark R. Sanderson, Veselkov Dennis A., Sanderson Mark R., L Mark Fisher, Veselkov, DA, Mark R Sanderson, Fisher, L. Mark, Dennis A. Veselkov, Katherine E. McAuley, Laponogov Ivan, Sanderson, Mark R., Laponogov, Ivan, McAuley Katherine E., Dennis A Veselkov, Pan, XS, L. Mark Fisher   +27 more
core   +1 more source

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases [PDF]

, 2007
Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase ...
GIARETTA G, COMUZZI V, Palumbo, M, Leo, E, Mitchenall, LA, Richter, SN, Maxwell, A, Fisher, LM, RICHTER, SARA, Giaretta, G, LEO E, MAXWELL A, Comuzzi, V, FISHER LM, MITCHENALL LA, PALUMBO, MANLIO   +15 more
core   +1 more source

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

eLife, 2018
Gyrase is a unique type IIA topoisomerase that uses ATP hydrolysis to maintain the negatively supercoiled state of bacterial DNA. In order to perform its function, gyrase undergoes a sequence of conformational changes that consist of concerted gate ...
Katarzyna M Soczek, Tim Grant, Peter B Rosenthal, Alfonso Mondragón   +3 more
doaj   +1 more source

Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis [PDF]

, 2014
Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Dehio, Christoph, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Frédéric V. Stanger, Tilman Schirmer (585552), Christoph Dehio (200951)   +9 more
core   +1 more source

The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA [PDF]

, 2011
<b>Background</b> Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity.
Caroline A. Austin, Kathryn L Gilroy, Caroline A Austin, Austin Caroline A., Austin, C.A., Gilroy Kathryn L., Gilroy, K.L., Kathryn L. Gilroy   +7 more
core   +2 more sources

Molecular Docking for the Development of Alternative Therapies against Leishmaniasis

Chemistry Proceedings, 2023
Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata, Christian Alcívar, Martin Lavecchia, Ana Poveda   +3 more
doaj   +1 more source

Tricking enzymes in living cells: a mechanism-based strategy for design of DNA topoisomerase biosensors

Journal of Nanobiotechnology, 2021
Most activity-based molecular probes are designed to target enzymes that catalyze the breaking of chemical bonds and the conversion of a unimolecular substrate into bimolecular products.
Sai Ba, Guangpeng Gao, Tianhu Li, Hao Zhang   +3 more
doaj   +1 more source

Archaea: A Gold Mine for Topoisomerase Diversity

Frontiers in Microbiology, 2021
The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the ...
Florence Garnier, Florence Garnier, Mohea Couturier, Hélène Débat, Hélène Débat, Marc Nadal, Marc Nadal   +6 more
doaj   +1 more source

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in <i>Mycobacterium abscessus</i>. [PDF]

mLife
mLife, EarlyView.
Wang S, Alam MS, Yusuf B, Zhang J, Lu Z, Zhang X, Hameed HMA, Khatun MS, Li C, Li L, Vatlin AA, Belachew AM, Tian X, Gao Y, Fang C, Zhang RP, Li J, Wang X, Feng L, Wan L, Zhang T.   +20 more
europepmc   +2 more sources