Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner [PDF]
Genome BiologyBackground Regulation of the target DNA cleavage activity of CRISPR/Cas has naturally evolved in a few bacteria or bacteriophages but is lacking in higher species.
Yuxuan Zhang +5 more
doaj +2 more sources
The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. [PDF]
Biophys Rev, 2016 Seol Y, Neuman KC.
europepmc +5 more sources
Regulation of DNA Topology in Archaea: State of the Art and Perspectives. [PDF]
Mol MicrobiolVillain P, Basta T.
europepmc +2 more sources
A review on nonlinear DNA physics [PDF]
Royal Society Open Science, 2020 The study and the investigation of structural and dynamical properties of complex systems have attracted considerable interest among scientists in general and physicists and biologists in particular.
Dalibor Chevizovich +4 more
doaj +1 more source
Data of transcriptional effects of the merbarone-mediated inhibition of TOP2
Data in Brief, 2022 Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves +6 more
doaj +1 more source
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. [PDF]
Sci Rep, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Gu M +5 more
europepmc +2 more sources
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
Cell Reports, 2021 Summary: Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation.
Andrés Herrero-Ruiz +6 more
doaj +1 more source
Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays. [PDF]
J Biol Chem, 2019 Bass MV +4 more
europepmc +2 more sources
A topological analysis of difference topology experiments of condensin with topoisomerase II
Biology Open, 2020 An experimental technique called difference topology combined with the mathematics of tangle analysis has been used to unveil the structure of DNA bound by the Mu transpososome. However, difference topology experiments can be difficult and time consuming.
Soojeong Kim, Isabel K. Darcy
doaj +1 more source
Model for topology dependent DNA binding
, 2023 This package contains code that implements a model for topology-dependent binding to ...
Jan Lipfert (Utrecht University)
core +1 more source