Results 111 to 120 of about 1,893,090 (266)

A compactness preserving topology for products sets [PDF]

, 1975
The purpose of this thesis is to investigate the properties of certain topologies for a countable product of lattice isomorphic factor spaces. The idea of using lattice isomorphisms between factors to define a topology on a product space is due to ...
Howe, Thomas Lavern, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques

Journal of Translational Medicine
Background Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the comparative molecular pathogenesis
Simon Deycmar, Brendan J. Johnson, Karina Ray, George W. Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L. Dozier, Betsy Ferguson, Benjamin N. Bimber, John D. Olson, David L. Caudell, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, Emily C. Romero, Francois J. Villinger, Armando G. Burgos, Hannah C. Ainsworth, Lance D. Miller, Gregory A. Hawkins, Jeff W. Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J. Mark Cline   +24 more
doaj   +1 more source

Linking topology of large DNA molecules [PDF]

Physica A: Statistical Mechanics and its Applications, 2010
Double helix DNA molecules, the carriers of genetic instructions in cells, are strongly affected by their topological properties. Two distinct and biologically important types of linking are associated with double helix DNAs: 'internal' linking of the two strands of individual double helices, and 'external' linking of separate double helix DNAs ...
openaire   +2 more sources

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

The Topology of Branching Universes [PDF]

, 2005
The purpose of this paper is to survey the possible topologies of branching space-times, and, in particular, to refute the popular notion in the literature that a branching space-time requires a non-Hausdorff ...
McCabe, Gordon, Gordon Mccabe
core  

Application of Algebraic Topology to Homologous Recombination of DNA

iScience, 2018
Summary: Brouwer's fixed point theorem, a fundamental theorem in algebraic topology proved more than a hundred years ago, states that given any continuous map from a closed, simply connected set into itself, there is a point that is mapped unto itself ...
Ido Braslavsky, Joel Stavans
doaj   +1 more source

Variable DNA topology is an epigenetic generator of physiological heterogeneity in bacterial populations. [PDF]

Mol Microbiol, 2023
Dorman CJ.
europepmc   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling

Nature Communications
RNA polymerase (RNAP) must unwind duplex DNA prior to transcription initiation. In bacteria, unwinding starts at a DNA motif called the promoter −10 element. Specifically, non-template strand bases interact with RNAP to trigger the process.
David Forrest, Emily A. Warman, David C. Grainger   +2 more
doaj   +1 more source