Results 121 to 130 of about 2,257,590 (274)
The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis [PDF]
, 2012 Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide ...
Summers, Emma Louise
core
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling
Nature CommunicationsRNA polymerase (RNAP) must unwind duplex DNA prior to transcription initiation. In bacteria, unwinding starts at a DNA motif called the promoter −10 element. Specifically, non-template strand bases interact with RNAP to trigger the process.
David Forrest +2 more
doaj +1 more source
From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits
Advanced Science, EarlyView.This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang +5 more
wiley +1 more source
Regulation of DNA topology in mycobacteria [PDF]
, 2004 DNA topoisomerases catalyse essential DNA transaction processes in order to attain the balanced topology of the genome. Contrasting activities of DNA topoisomerase I and DNA gyrase result in the maintenance of topological homeostasis.
Nagaraja, V
core +2 more sources
Advanced Science, EarlyView.A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang +6 more
wiley +1 more source
Variable DNA topology is an epigenetic generator of physiological heterogeneity in bacterial populations. [PDF]
Mol Microbiol, 2023 Dorman CJ.
europepmc +1 more source
Rational design of topology-defined DNA nanoframeworks for antigen delivery and cross-presentation
Journal of NanobiotechnologyDNA nanoframeworks (DNFs) provide structurally programmable platforms for antigen delivery, yet how framework topology influences antigen cross-presentation remains unclear.
Ying Cao +8 more
doaj +1 more source
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
Running Title: DNA replication and topology
, 2020 22 p.-5 fig.During replication, the topology of DNA changes continuously in response to well‐known activities of DNA helicases, polymerases, and topoisomerases.
Hernandez, Pablo +5 more
core +1 more source