Results 181 to 190 of about 2,257,590 (274)

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Surface topology /

This updated and revised edition of a widely acclaimed and successful text for undergraduates examines topology of recent compact surfaces through the development of simple ideas in plane geometry.
Gardiner, Cyril F., Firby, P. A.
core  

RNA interacts with topoisomerase I to adjust DNA topology. [PDF]

Mol Cell
Bhola M, Abe K, Orozco P, Rahnamoun H, Avila-Lopez P, Taylor E, Muhammad N, Liu B, Patel P, Marko JF, Starner AC, He C, Van Nostrand EL, Mondragón A, Lauberth SM.   +14 more
europepmc   +1 more source

Re‐Thinking Electronic Circuit Design Through Emerging Reconfigurable Field Effect Transistors

Advanced Science, EarlyView.
Graphical illustration of reconfigurable field effect transistor (RFET) operation modes, including n‐type, p‐type, and ambipolar transport, as well as their areas of application discussed in this review: digital circuit design, analog circuit design, post‐Shannon computing, and sensing. ABSTRACT Reconfigurable field‐effect transistors, short RFETs, are
Jens Trommer, Juan P. Martinez, Yuxuan He, Giulio Galderisi, Katrin Pingen, Eduardo Sergio Oliveros‐Mata, Lisa Tellis, Cigdem Cakirlar, Christoph Beyer, Brojogopal Sapui, Joachim Knoch, Klaus Hofmann, Sandro Carrara, Eugenio Cantatore, Max C. Lemme, Ian O'Connor, Akash Kumar, Andre Heinzig, Thomas Mikolajick, Walter M. Weber   +19 more
wiley   +1 more source

An Integrated Artificial Intelligence Framework for Nanomedicine Engineering

Advanced Science, EarlyView.
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong, Qin Luo, Xinyi Ding, Chaoqi Lu, Ru Zhang, Qingqing Tan, Zhiqing Pang, Defang Ouyang, Dongsheng Li, Jiaxuan Xia, Jianxin Wang   +10 more
wiley   +1 more source

Sequence Dependent Denaturation in Small DNA Circles: A Multiscale Approach

, 2014
The discovery of the structure of duplex DNA revealed how cells store genetic information. However, we are far from understanding the more complex biological question of how this information is regulated and processed by the cell.
Harris, Sarah
core  

Revised role for Hfq bacterial regulator on DNA topology. [PDF]

Sci Rep, 2018
Malabirade A, Partouche D, El Hamoui O, Turbant F, Geinguenaud F, Recouvreux P, Bizien T, Busi F, Wien F, Arluison V.   +9 more
europepmc   +1 more source

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

Advanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu, Xinyuan Zhang, Xinyi Chen, Jiaxin Shi, Meng Xu, Fuhao Wang, Jinling Lv, Jiaman Sun, Weiyi Niu, Zihan Liu, Li Li, Fufeng Liu, Xiangming Wang   +12 more
wiley   +1 more source

Bacterial chromatin proteins, transcription, and DNA topology: Inseparable partners in the control of gene expression. [PDF]

Mol Microbiol
Hustmyer CM, Landick R.
europepmc   +1 more source

Modelling and DNA topology of compact 2-start and 1-start chromatin fibres. [PDF]

Nucleic Acids Res, 2019
Wu C, Travers A.
europepmc   +1 more source