Results 211 to 220 of about 2,257,590 (274)
Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning
Advanced Science, EarlyView.Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin +13 more
wiley +1 more source
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni +14 more
wiley +1 more source
Advanced Science, EarlyView.Here, we present SensEnhance, a modular genetic circuit that converts leaky, low‐dynamic‐range promoter signals into tightly controlled, high‐dynamic‐range outputs. Applied to mechanosensing and IL‐6‐responsive promoters, SensEnhance increases fold changes from 2.6‐ and 2.5‐fold in promoter‐only configurations to over 20‐ and 14‐fold, respectively ...
Miguel Baños +4 more
wiley +1 more source
Ligand‐Ratio–Tuned DNA Nanocarriers Overcome Bladder Barriers for Ultralow‐Dose Intravesical Therapy
Advanced Science, EarlyView.A programmable DNA framework drug carrier coordinates barrier transport, tumor targeting, and drug delivery through ligand‐ratio engineering. Systematic exploration of the Sgc8/fluorocarbon design space reveals a nonlinear optimal balance between penetration and cellular engagement, translating multifunctional integration into durable bladder tumor ...
Dunfang Liu +5 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.Compact circuits based on contact‐controlled transistors are well‐suited to unsupervised thermal management, sensitive temperature measurement, or temperature‐stable current references. Demonstrated on flexible microcrystalline silicon and supported by simulation, the approach does not require supply voltage regulation, remains manufacturable across ...
Eva Bestelink +6 more
wiley +1 more source
The interplay between DNA topology and accessory factors in site-specific recombination in bacteria and their bacteriophages. [PDF]
Sci Prog, 2016 Dorman CJ, Bogue MM.
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta +3 more
wiley +1 more source