Results 41 to 50 of about 2,257,590 (274)
Hittite Journal of Science and Engineering, 2019 I n this study novel triplex forming DNA probes have been designed in order to detect Ag+ ion in low concentrations. The use of triplex forming oligonucleotides is a convenient in applications of sensing biomolecules due to their sequence specificity and
Osman Doluca
doaj +1 more source
“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process
Frontiers in Molecular Biosciences, 2020 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5′-phosphate, 3′-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Almudena Serrano-Benítez +4 more
doaj +1 more source
DNA Topology: Dynamic DNA Looping [PDF]
Current Biology, 2006 The DNA in repressive loops is often tightly bent. DNA flexibility imposes significant constraints on their topology suggesting that they may exist as perturbations in plectonemic DNA.
openaire +2 more sources
Topological entropy of DNA sequences [PDF]
Bioinformatics, 2011 Abstract Motivation: Topological entropy has been one of the most difficult to implement of all the entropy-theoretic notions. This is primarily due to finite sample effects and high-dimensionality problems. In particular, topological entropy has been implemented in previous literature to conclude that entropy of exons is higher than ...
openaire +3 more sources
Hsmar1 transposition is sensitive to the topology of the transposon donor and the target. [PDF]
PLoS ONE, 2013 Hsmar1 is a member of the Tc1-mariner superfamily of DNA transposons. These elements mobilize within the genome of their host by a cut-and-paste mechanism.
Corentin Claeys Bouuaert +1 more
doaj +1 more source
Nature Communications, 2023 Genome topology is tied to R-loop formation and genome stability. However, the regulatory mechanism remains to be elucidated. By establishing a system to sense the connections between R-loops and genome topology states, we show that inhibiting DNA ...
Qin Li +7 more
doaj +1 more source
Structural basis for allosteric regulation of Human Topoisomerase IIα
Nature Communications, 2021 Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing ...
Arnaud Vanden Broeck +5 more
doaj +1 more source
Archaea: A Gold Mine for Topoisomerase Diversity
Frontiers in Microbiology, 2021 The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the ...
Florence Garnier +6 more
doaj +1 more source
DNA topology: Topological transformation of DNA by reaction of cisplatin-DNA-core histone complexes with human DNA topoisomerase [PDF]
Nucleic Acids Symposium Series, 2002 Cis-diamminedichloroplatinium(II), an active antitumor agent binds to core-histone -SV40 DNA complexes prepared by reaction of DNA with core-histone, and alters the fiber-like structure into the loosened structure. In order to model the cisplatin-modified chromatin complexes in cell, the complexes were reacted with human DNA topo II.
Shigeki, Kobayashi +4 more
openaire +2 more sources
Physical Characterization of Gemini Surfactant-Based Synthetic Vectors for the Delivery of Linear Covalently Closed (LCC) DNA Ministrings. [PDF]
PLoS ONE, 2015 In combination with novel linear covalently closed (LCC) DNA minivectors, referred to as DNA ministrings, a gemini surfactant-based synthetic vector for gene delivery has been shown to exhibit enhanced delivery and bioavailability while offering a ...
Chi Hong Sum +3 more
doaj +1 more source