Results 71 to 80 of about 2,257,590 (274)
SLFN5-mediated chromatin dynamics sculpts higher-order DNA repair topology
, 2023 Original data for manuscript "SLFN5-mediated chromatin dynamics sculpts higher-order DNA repair topology ...
huang, J (via Mendeley Data) +1 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy
Nature CommunicationsDNA topology is essential for regulating cellular processes and maintaining genome stability, yet it is challenging to quantify due to the size and complexity of topologically constrained DNA molecules.
Elizabeth P. Holmes +14 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
, 2019 Difference topology: The DNA path within a high-order DNA-protein assembly can be revealed from the topology of DNA knots and links formed by the action of Flp or Cre site-specific recombinase on target sites placed close to (and flanking) the assembly ...
Jayaram, Makkuni
core +1 more source
Nature CommunicationsRNA polymerase (RNAP) is a processive motor that modulates DNA supercoiling and reshapes DNA structures. The feedback loop between the DNA topology and transcription remains elusive.
Jihee Hwang +8 more
doaj +1 more source
A TOPOLOGICAL FRAMEWORK FOR DNA REPLICATION
JP Journal of Geometry and TopologyDNA replication, a vital biological function, can be effectively modelled as a two-component link. As this link splits during replication, the double-helical nature of DNA leads to the formation of supercoils¾essentially, entanglement. To untangle these supercoils, DNA segments must be exchanged, a task performed by enzymes called topoisomerases.
Mohamad, Abdul Adheem, Yashiro, Tsukasa
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Determining the topology of stable protein–DNA complexes
, 2013 Difference topology is an experimental technique that can be used to unveil the topological structure adopted by two or more DNA segments in a stable protein-DNA complex.
Darcy, Isabel K, Vazquez, Mariel
core +1 more source
Increasing the activity of DNAzyme based on the telomeric sequence: 2’-OMe-RNA and LNA modifications
Open Chemistry, 2019 2’-OMe-RNA analogues and LNA point modifications of DNA oligonucleotides were applied for the modulation of the G-quadruplex topology and enhancement of peroxidase activity of the resulting DNAzymes.
Kosman J., Żukowski K., Juskowiak B.
doaj +1 more source