Results 81 to 90 of about 124,583 (279)
Advanced Functional Materials, EarlyView.DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen +3 more
wiley +1 more source
DNA Topology and Global Architecture of Point Centromeres
Cell Reports, 2015 DNA is wrapped in a left-handed fashion around histone octasomes containing the centromeric histone H3 variant CENP-A. However, DNA topology studies have suggested that DNA is wrapped in a right-handed manner around the CENP-A nucleosome that occupies ...
Ofelia Díaz-Ingelmo +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement
AIP Advances, 2013 We report strong evidence for a localized transition in the size variation of circular DNA between strong and moderate regimes of slitlike confinement. A novel and rigorous statistical analysis was applied to our recent experimental measurements of DNA ...
Elizabeth A. Strychalski +2 more
doaj +1 more source
Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis [PDF]
, 2014 Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Stanger, Frédéric V. +9 more
core +1 more source
Shaping Matter with Acoustic Waves: From Particles to Functional Structures
Advanced Functional Materials, EarlyView.Acoustic‐directed assembly is reviewed as a materials‐oriented strategy for organizing particles, polymers, metals, and biological systems into functional structures. The review distinguishes reversible manipulation from permanent structure formation through medium fixation, particle fixation, and in situ material generation, highlighting routes toward
Avraham Kenigsberg +5 more
wiley +1 more source
Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
Nature Communications, 2016 Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target ...
Nathan D. Jones +6 more
doaj +1 more source
Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.
PLoS ONE, 2013 Hot spot mutant p53 (mutp53) proteins exert oncogenic gain-of-function activities. Binding of mutp53 to DNA is assumed to be involved in mutp53-mediated repression or activation of several mutp53 target genes.
Marie Brázdová +11 more
doaj +1 more source
Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance
Molecules, 2020 Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and
Natassja G. Bush +3 more
doaj +1 more source
Creation of electrical knots and observation of DNA topology
New Journal of Physics, 2021 Knots are fascinating topological structures that have been observed in various contexts, ranging from micro-worlds to macro-systems, and are conjectured to play a fundamental role in their respective fields.
Tian Chen +5 more
doaj +1 more source