Results 121 to 130 of about 21,302 (228)

Assessing the efficacy of a single-cycle measurement and adjustment strategy for direct oral anticoagulants in frail older patients: rationale and design of the DOAC-FRAIL randomized controlled trial

Research and Practice in Thrombosis and Haemostasis
Background: Frail older patients are at high risk of both thromboembolism and bleeding, making anticoagulant therapy challenging. Direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists because of comparable efficacy and lower ...
Fabienne J.H. Magdelijns, Melanie J. de Jong, Kristien Winckers, Astrid D.H. Brys, Dionne C.W. Braeken, Sander M.J. van Kuijk, Henri M.H. Spronk, Hans Bosman, Daisy J.A. Janssen, Robin M.J.M. van Geel, Dave Hellenbrand, Hugo ten Cate, Yvonne Henskens   +12 more
doaj   +1 more source

Catheter‐Based Therapies for Intermediate‐High Risk Pulmonary Embolism: A Protocol for a Systematic Review With Bayesian Pairwise and Network Meta‐Analyses

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Intermediate‐high risk pulmonary embolism (PE) represents a clinically challenging subgroup of acute PE, characterized by right ventricular dysfunction and increased risk of hemodynamic deterioration despite treatment with anticoagulation therapy.
Jacob Hindborg Hovmann, Thomas Skjoldborg Sornn‐Friese, Frederik Færgemann Lau, Niels Brandt, Isak Mazanti Cold, Janus C. Jakobsen, Jasmin Dam Lukoschewitz, Alasdair D. Henderson, Anne Sophie Overgaard Olesen, Jens Dahlgaard Hove, Jesper Kjærgaard, Johannes Grand   +11 more
wiley   +1 more source

Impact of Atrial Fibrillation on the Risk of Thrombosis and Bleeding for Patients With Polycythemia Vera and Essential Thrombocytosis in the Real World

American Journal of Hematology, Volume 101, Issue 9, Page 2463-2468, September 2026.
Rodrigo Ortega Perez, Luis Manuel Domínguez Rodríguez, Francisca Ferrer‐Marín, Beatriz Cuevas Ruíz, Clara Martínez Valverde, Patricia Vélez Tenza, María Isabel Mata Vázquez, Adrián Segura Díaz, María Laura Fox, Elvira Mora, Manuel Mateo Pérez Encinas, Mercedes Gasior Kabat, Gonzalo Carreño‐Tarragona, Rafael Andrés del Orbe, Gonzalo Caballero‐Navarro, Elena Magro Mazo, Ana Pardo Sanz, José Luis Zamorano Gómez, Alberto Álvarez Larrán, Valentín Garcia‐Gutierrez   +19 more
wiley   +1 more source

P‐CAB vs. PPI for Upper Gastrointestinal Bleeding Prevention in Patients With Atherothrombotic Disease on Antithrombotic Therapy: A CDM Cohort Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 499-506, August 2026.
In patients with atherothrombotic disease on antithrombotic therapy, P‐CABs demonstrated a significantly superior protective effect against clinically significant upper GI haemorrhage compared to PPIs (aHR 0.22; p = 0.016). This real‐world study highlights P‐CABs as a more potent gastroprotective strategy for high‐risk populations requiring intensive ...
Min Joo Yoon, Soyoung Lee, Hye‐Kyung Jung, Min‐ho Kim, Suna Yu, Eui Sun Jeong, Chung Hyun Tae   +6 more
wiley   +1 more source

“Everyone's Responsibility and No‐One's Responsibility”: A Thematic Analysis of a Roundtable on the Complex Problem of Secondary Stroke Prevention in Australia

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Background Around one in four people with stroke will have a recurrent stroke. The risk can be reduced through medication and lifestyle changes, but many have poor risk factor control post‐stroke. There is no nationally recognised model of care for stroke secondary prevention, and inadequate secondary prevention may be a complex problem that ...
Seamus Barker, Dominique Cadilhac, Jan Cameron, Marie‐Louise Bird, Liam Johnson, Coralie English, Kyra Hamilton, Robyn A. Clark, Timothy Kleinig, Stephanie Smith, Beth Crane, Brian Beh, Kim Beesley, Jennifer Muller, Ramesh Sahathevan, Helen Dewey, Carlos Garcia‐Esperon, Mark Nelson, Seana Gall   +18 more
wiley   +1 more source

Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality

Cancer, Volume 132, Issue 14, 15 July 2026.
Patients with atrial fibrillation (AF) and cancer treated with direct oral anticoagulants (DOACs) had a lower risk of all‐cause mortality, cardiovascular events (CVEs), but not bleeding events, compared to patients treated with vitamin K antagonists (VKAs) with low anticoagulation quality.
Danilo Menichelli, Vito Maria Daniele Cormaci, Gianluca Gazzaniga, Irma Bisceglia, Massimiliano Camilli, Daniela Poli, Emilia Antonucci, Roberto Pola, Paolo Santini, Pasquale Pignatelli, Daniele Pastori, on behalf of the START2 Registry Investigators   +11 more
wiley   +1 more source

Disparities in the real-world prescription pattern of oral anticoagulants for US Medicare beneficiaries: a geospatial analysis

BMJ Open
Objectives This study was conducted to examine urban–rural differences in the real-world prescribing pattern of oral anticoagulants and geographic variations in the prescribing pattern among clinicians serving Medicare beneficiaries in the USA.Design A ...
Yong Zhu, Dong Liang, Jingrui Zou
doaj   +1 more source

Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

Research and Practice in Thrombosis and Haemostasis
Background: The incidence of cardiovascular diseases is increasing in persons with hemophilia A (HA). Therefore, anticoagulant therapy based on direct oral anticoagulants (DOACs) may be needed, despite the bleeding risk.
Sylvain Lamoine, Vincent Jury, Virginie Fourneyron, Jonathan Douxfils, Dorian Teissandier, Laurie Talon, Thomas Sinegre, Aurélien Lebreton   +7 more
doaj   +1 more source

Effects of DOACs on Mouse Melanoma Metastasis and the Inhibitory Mechanism of Edoxaban, a Factor Xa-Specific DOAC

TH Open
AbstractDirect oral anticoagulants (DOACs) have been widely used in patients with thromboembolism. We previously reported that among DOACs, edoxaban (EDX), a factor Xa (FXa)-specific DOAC, most effectively inhibited the growth of syngeneic non-metastatic murine colon cancer cells implanted in mice via the protease-activated receptor 2 (PAR2) pathway ...
Hiramoto, Keiichi, Watanabe, Taisei, Imai, Masashi, Suzuki, Koji   +3 more
openaire   +2 more sources

Impact of levetiracetam on direct oral anticoagulant level and outcomes among older Asian patients with atrial fibrillation

Frontiers in Pharmacology
ObjectiveThis purpose of this study is to analyze the influence of levetiracetam (LEV) on direct oral anticoagulant (DOAC) exposure and its implications for clinical outcomes.MethodsThis investigation comprised a retrospective cohort study utilizing the ...
Yu-Ting Huang, Tzu-Ling Chen, Yun-Lin Huang, Ching-Hua Kuo, Yu-Fong Peng, Sung-Chun Tang, Jiann-Shing Jeng, Chih-Feng Huang, Chih-Feng Huang, Chih-Feng Huang, Shin-Yi Lin, Shin-Yi Lin, Fang-Ju Lin, Fang-Ju Lin, Fang-Ju Lin   +14 more
doaj   +1 more source