Results 131 to 140 of about 137,598 (276)
Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort
Annals of Neurology, EarlyView.Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov +42 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura +8 more
wiley +1 more source
Dijete, vrtić, obitelj : Časopis za odgoj i naobrazbu predškolske djece namijenjen stručnjacima i roditeljima, 2008 Budući da u suvremenom svijetu starost, odnosno zrela životna dob, ima posve drugi status u odnosu na negdašnja vremena, bitno se promijenila i uloga djedova i baka u životu djece. Članak će poslužiti odgajateljima i roditeljima kako bi se bolje razumjele potrebe starijih ljudi koje imaju utjecaj na obitelj i na odnose među njezinim članovima.
openaire +2 more sources
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, EarlyView.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
, 2020 ADHD is most often mentioned in addition to children and there are not enough researches focused on the adult population. Because of that this dissertation focuses on ADHD in adulthood. Therefore, the main goal of this paper is to present the unique perspective of adults with ADHD in the area of changing symptoms, interpersonal relationships and ...
openaire +1 more source
Controlled Delivery and Light‐Induced Release of Magic Spot Nucleotides in Escherichia coli
Angewandte Chemie International Edition, EarlyView.We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp +12 more
wiley +1 more source
Applications in Plant Sciences, EarlyView.Abstract Premise Genebanks must maintain viable seeds for decades. Seeds that germinate are clearly alive, but some seeds, often from wild populations, do not germinate because they are dormant, empty, aged, or damaged (D.E.A.D.). This work evaluates the effects of D.E.A.D.
Christina Walters +33 more
wiley +1 more source
The Anatomical Record, EarlyView.A new musculoskeletal reconstruction and revision of the cranio‐mandibular anatomy of the Devonian arthrodire placoderm Dunkleosteus terrelli from a comparative and functional anatomical perspective. Dunkleosteus is a specialized arthrodire with many specializations for feeding on large vertebrates, and many of its features are part of broader ...
Russell K. Engelman +4 more
wiley +1 more source
Archaeology in Oceania, EarlyView.ABSTRACT Shell middens in Gippsland along the eastern half of Victoria's coastline have usually been characterised as small, short‐duration camp sites with relatively low shell densities and low taxonomic diversity. Here we present new excavation results from a dense, high‐diversity site at Red Bluff near the eastern end of GunaiKurnai Country, a ...
Patrick Faulkner +17 more
wiley +1 more source
Acute cardio-centric haemodynamic management preserves chronic cardiovascular function in pigs with high-thoracic spinal cord injury. [PDF]
J PhysiolWilliams AM +13 more
europepmc +1 more source