Results 91 to 100 of about 336,807 (309)
Two-Step Covalent Docking with Attracting Cavities
, 2023 Due to their various advantages, interest in the development of covalent drugs has been renewed in the past years. It is therefore important to accurately describe and predict their interactions with biological targets by computer-aided drug design tools,
Ute F., Röhrig +2 more
core +1 more source
Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Satellite docking simulation based on HIL hybrid contact model
, 2013 This paper briefly presents a hardware-in-the-loop (HIL) docking simulator concept. A critical requirement for the docking simulation of the HIL simulator is that its 6-degree of freedom (DOF) robots have to mimic the dynamic response of two satellites ...
Boge, Toralf +3 more
core
FELDs: mechanical design and development of a tethered soft docking setup for microgravity testing [PDF]
, 2022 This thesis presents the mechanical design and development of the FELDs docking technology. The system is provided with a target subsystem and a shoot mechanism to eject the probe.
Cavinato, Alessandro
core
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Global Medical GeneticsDementia is a syndrome that can cause a number of progressive illnesses that affect memory, thinking, and ability to perform everyday tasks. Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. AD is
Asif Mir, Zainab Kamran, Wajid Iqbal
doaj +1 more source
Docking Foundations: From Rigid to Flexible Docking
Despite the development of methods for the experimental determination of protein structures, the dissonance between the number of known sequences and their solved structures is still enormous. This is particularly evident in protein-protein complexes. To fill this gap, diverse technologies have been developed to study protein-protein interactions (PPIs)
openaire +3 more sources
Using Robots for Advanced Rendezvous and Docking Simulation
, 2012 For human spaceflight missions rendezvous and docking (RvD) of two spacecrafts is state of the art today. For future satellite missions this close operation scenario becomes more and more interesting in the last years.
Boge, Toralf +3 more
core
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source