Results 101 to 110 of about 336,807 (309)
Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I
, 2011 Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction.
Feroz Khan +5 more
core +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Message of Governor George Docking to the Kansas Legislature, 1959
, 1959 January 1959.Water and Soil Conservation -- Retirement System -- Home Rule -- Right to Know -- Education -- Mentally Retarded -- Social Welfare -- Fish, Game and Recreation -- Civil Rights -- Labor -- Centennial -- Elections -- Anti-Corrupt Practices ...
Kansas. Governor (1957-1961 : Docking)
core
Conceptual Framework and Methodology for Analysing Previous Molecular Docking Results [PDF]
, 2019 Modern drug discovery relies on in-silico computational simulations such as molecular docking. Molecular docking models biochemical interactions to predict where and how two molecules would bind.
Temelkovski, D.
core +1 more source
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Other title: Inaugural address of Governor George Docking
, 1959 Second inaugural ceremonies, January twelfth, nineteen hundred fifty ...
Kansas. Governor (1957-1961 : Docking)
core
Advanced Science, EarlyView.Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang +14 more
wiley +1 more source
Message of Governor George Docking to the Kansas Legislature, 1957
, 1957 application/pdf; January ...
Kansas. Governor (1957-1961 : Docking)
core
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source