Results 141 to 150 of about 697,276 (400)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Maritime Warfare; the Importance to the British Empire of a Complete System of Telegraphs, Coaling Stations, and Graving Docks [PDF]

, 1877
D. Currie
openalex   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Smiles2Dock: an open large-scale multi-task dataset for ML-based molecular docking [PDF]

arXiv
Docking is a crucial component in drug discovery aimed at predicting the binding conformation and affinity between small molecules and target proteins. ML-based docking has recently emerged as a prominent approach, outpacing traditional methods like DOCK and AutoDock Vina in handling the growing scale and complexity of molecular libraries. However, the
arxiv  

DISCUSSION. ROYAL DOCKS APPROACHES IMPROVEMENT, LONDON. (INCLUDES PLATES). [PDF]

, 1936
D KENNEDY, G. Humphreys, David Owen, Caroline Bressey, R V ALLIN, E J BUCKTON, F M G DU PLAT TAYLOR, J CUEREL, Henry Hay, H E ALDINGTON   +9 more
openalex   +1 more source

Bridging Molecular Docking to Molecular Dynamics in Exploring Ligand-Protein Recognition Process: An Overview

Frontiers in Pharmacology, 2018
Computational techniques have been applied in the drug discovery pipeline since the 1980s. Given the low computational resources of the time, the first molecular modeling strategies relied on a rigid view of the ligand-target binding process.
V. Salmaso, S. Moro
semanticscholar   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm

Nucleic Acids Res., 2018
Protein–peptide interactions are crucial in many cellular functions. Therefore, determining the structure of protein–peptide complexes is important for understanding the molecular mechanism of related biological processes and developing peptide drugs ...
Pei-Zhang Zhou, Bowen Jin, Hao Li, Shengyou Huang   +3 more
semanticscholar   +1 more source

Recovery of spinning satellites [PDF]

The behavior of a space tug and a spinning satellite in a coupled configuration was simulated and analyzed. A docking concept was developed to investigate the requirements pertaining to the design of a docking interface.
Coppey, J. M., Mahaffey, W. R.
core   +1 more source

Autonomous homing and docking tasks for an underwater vehicle

, 2009
This paper briefly introduces a strategy for autonomous homing and docking tasks using an autonomous underwater vehicle. The control and guidance based path following for those tasks are described in this work.
Wilson, P. A.
core   +1 more source