Results 141 to 150 of about 336,807 (309)

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Novel Cyanopyrimidine Derivatives as Potential Anticancer Agents

Molecules
The Bcl-2 family’s anti-apoptotic proteins, particularly Mcl-1, offer a viable avenue for cancer treatment since cancer cells can undergo apoptosis when their selective suppression occurs.
Rania H. Abd El-Hameed, Omnia Aly, Mariem E. Mohamed, Amal F. Gharib, Mosaad S. Mohamed, Ashraf Ali, Zainab M. Khoder, Heba Taha, Samar S. Fatahala   +8 more
doaj   +1 more source

Other title: Legislative Message and Budget Report Other title: Message of Robert B. Docking to the Kansas Legislature

, 1968
application/pdf; "January 11, 1968."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core  

Simultaneous clustering analysis with molecular docking in network pharmacology for type 2 antidiabetic compounds

, 2017
The database of drug compounds and human proteins plays a very important role in identifying the protein target and the compound in drug discovery. Recently, a network pharmacology approach was established by updating the research paradigm from the ...
Afendi, Farit Mochamad, Farit Mochamad Afendi, I Made Sumertajaya, Sumertajaya, I Made, Nur Azizah Komara Rifai, Rifai, Nur Azizah Komara   +5 more
core   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Other title: Legislative Message and Budget Report Other title: Message of Robert B. Docking to the Kansas Legislature

, 1970
application/pdf; "January 13, 1970."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core  

Tail biting in pigs: is it possible to rear the heavy pig avoiding tail docking? [PDF]

, 2013
Tail biting in pigs has been identified as a behavioural problem for decades. It has serious consequences for animal welfare and for the income of the farmers The inability to prevent occurrence of this adverse behavior under commercial farm conditions ...
Scollo, A.
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Other title: Legislative Message and Budget Report Other title: Message of Robert B. Docking to the Kansas Legislature

, 1971
application/pdf; "January 20, 1971."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core