Results 161 to 170 of about 293,887 (293)

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III. [PDF]

Chem Res Toxicol
Grillberger K, Magel V, Leist M, Ecker GF.   +3 more
europepmc   +1 more source

Bioinformatics Project "Integrative Sequence, Structural and Docking Analysis of Class-A β- Lactamase (TEM-1, PDB: 1BTL) to Investigate Antibiotic Resistance Mechanisms"

Name -Deepak Kumar, Deepak Kumar Malav
openalex   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Regarding "The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses". [PDF]

Transl Psychiatry
Kristensen J.
europepmc   +1 more source

New insights on the disulfide bond status in soy proteins from mass spectrometry-pLink2 analysis and molecular docking

Longzheng Zhou, Xiaoli Feng, Xiangzhen Kong, Dawei Li, Yeming Chen, Caimeng Zhang, Yufei Hua   +6 more
openalex   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

MolOrgGPT: De Novo Generation via Large Language Models and Reinforcement Learning. [PDF]

J Chem Inf Model
Pardo PV, Toledano O, Marcos-Ayuso G, Quesada D, Campillo NE.   +4 more
europepmc   +1 more source

Synthesis, In silico Molecular Docking Studies and antimicrobial evaluation of Some New Anthracene Derivatives Tagged with Arylidene, Pyridine, Oxazole, and Chromene Moieties as Promising Inhibitors of Bacterial DNA gyrase

, 2022
Hemat M. Dardeer, Ahmed E. Taha, Arafat Toghan, Aboubakr H. Abdelmonsef, M Schiel, G Silbestri, M Alvarez, C Domini, R Gujjarappa, M Albratty, H Alhazmi, A Abu-Hashem, U Fathy, M Gouda, S Mishra, S Patel, C Halpani, T Orlando, P Salbego, F Farias, G Weimer, J Copetti, H Bonacorso, N Zanatta, M Hoerner, J Bern, M Martins, H Rashdan, A Abdel-Aziem, D El-Naggar, S Nabil, M Kasthuri, C Li, K Verma, O Russell, L Dickson, L Mccormick, L Bassit, F Amblard, R Schinazi, M Asif, M Imran, Abida, Y Nayak, S Gaonkar, E Saleh, H Trivedi, V Joshi, B Patel, L Turones, A Martins, L Moreira, S Da, J Fajemiroye, E Costa, A Moustafa, H El-Sayed, S El Rayes, H Morsy, S Abd-Allah, H Ismail, Abd El-Aal, M, Y Wu, Z Guo, W Deng, J Wang, Sd, S Dasari, S Tondepu, L Vadali, N Seelam, T Yakantham, R Sreenivasulu, G Alluraiah, M Tej, R Ramesh Raju, H Saadati-Moshtaghin, B Maleki, R Tayebee, S Kahrobaei, F Abbasinohoji, A Donaire-Arias, A Montagut, R Puig De La Bellacasa, R Estrada-Tejedor, J Teixid, J Borrell, G Singh, ; Diksha, Mohit, P Acharya, D Jethava, M Vasava, Z Bhavsar, M Bhoi, D Rajani, H Patel, S Jindal, K Meena   +99 more
openalex   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source