Results 261 to 270 of about 338,443 (309)
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Current Medicinal Chemistry, 2020
Background: Design of small molecules which are able to bind to the protein responsible for a disease is the key step of the entire process of the new medicine discovery. Atomistic computer modeling can significantly improve effectiveness of such design.
Vladimir B, Sulimov +2 more
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Background: Design of small molecules which are able to bind to the protein responsible for a disease is the key step of the entire process of the new medicine discovery. Atomistic computer modeling can significantly improve effectiveness of such design.
Vladimir B, Sulimov +2 more
openaire +2 more sources
2019
Protein-ligand docking simulation is central in drug design and development. Therefore, the development of web servers intended to docking simulations is of pivotal importance. SwissDock is a web server dedicated to carrying out protein-ligand docking simulation intuitively and elegantly.
Gabriela, Bitencourt-Ferreira +1 more
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Protein-ligand docking simulation is central in drug design and development. Therefore, the development of web servers intended to docking simulations is of pivotal importance. SwissDock is a web server dedicated to carrying out protein-ligand docking simulation intuitively and elegantly.
Gabriela, Bitencourt-Ferreira +1 more
openaire +2 more sources
Journal of Computer-Aided Molecular Design, 2011
The Darwinian model of evolution is an optimization strategy that can be adapted to docking. It differs from the common use of genetic algorithms, primarily in its acceptance of diverse solutions over finding "global" optima. A related problem is selecting compounds using multiple criteria.
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The Darwinian model of evolution is an optimization strategy that can be adapted to docking. It differs from the common use of genetic algorithms, primarily in its acceptance of diverse solutions over finding "global" optima. A related problem is selecting compounds using multiple criteria.
openaire +2 more sources
DOCKS: Docking System for Microsatellites
31st IAA Symposium on Small Satellite MissionsThe Space Rider Observer Cube (SROC) aims at demonstrating enabling technologies for inspection and docking. SROC will be transported into orbit by the reusable Space Rider (SR) vehicle, will perform inspection manoeuvres on SR, will dock back onto SR and will re-enter Earth's atmosphere inside the SR cargo bay. To perform the docking, SROC is provided
Luca Lion +13 more
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Fil: Schottlender, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales.
Prieto, Juan Manuel +5 more
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Prieto, Juan Manuel +5 more
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The American Journal of Nursing, 1954
Miss Johnson wearing the American Red Cross uniform of World War I. courses in home nursing and first aid, Florence mounted her bicycle and became Montclair's first visiting nurse. This she did as a volunteer, working under the auspices of the organization known as The New England Women.
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Miss Johnson wearing the American Red Cross uniform of World War I. courses in home nursing and first aid, Florence mounted her bicycle and became Montclair's first visiting nurse. This she did as a volunteer, working under the auspices of the organization known as The New England Women.
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discovery and molecular design. Docking simulations enable the prediction of ligand–protein interactions, binding affinities, and conformational orientations at the molecular level, supporting the identification of potent bioactive compounds prior to synthesis.
Hidayanti +4 more
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Hidayanti +4 more
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Alternative Law Journal, 2016
The chequered history of the case of Gerard Baden-Clay has been played out in the media of Queensland, Australia and the world for the last five years. The case culminated most recently with the High Court overturning an earlier decision of the Court of Appeal, and replacing Baden-Clay's manslaughter conviction for one of murder.
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The chequered history of the case of Gerard Baden-Clay has been played out in the media of Queensland, Australia and the world for the last five years. The case culminated most recently with the High Court overturning an earlier decision of the Court of Appeal, and replacing Baden-Clay's manslaughter conviction for one of murder.
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2008
Molecular docking is a key tool in structural molecular biology and computer-assisted drug design. The goal of ligand-protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known three-dimensional structure. Successful docking methods search high-dimensional spaces effectively and use a scoring function that ...
Garrett M, Morris, Marguerita, Lim-Wilby
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Molecular docking is a key tool in structural molecular biology and computer-assisted drug design. The goal of ligand-protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known three-dimensional structure. Successful docking methods search high-dimensional spaces effectively and use a scoring function that ...
Garrett M, Morris, Marguerita, Lim-Wilby
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The FEBS Journal, 2010
Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor‐associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2‐associated binder/Daughter of Sevenless, insulin receptor substrate,
Tilman, Brummer +2 more
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Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor‐associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2‐associated binder/Daughter of Sevenless, insulin receptor substrate,
Tilman, Brummer +2 more
openaire +2 more sources