Results 161 to 170 of about 84,234 (259)

Identification and expression validation of key genes of Xiaozhengtongluo formula in the treatment of diabetic nephropathy by Mendelian randomization. [PDF]

Funct Integr Genomics
Liu Z, Liu M, Wu H, Zhang Y, Chen Z, Wei X, Ma Y, Wang X, Gao H, Zheng J, Liang J.   +10 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Experimental Study on Anxiolytic and Antidepressant Effects of Zhi-Chi-Jie-Yu Granules in CUMS Mice and Prediction of Underlying Molecular Mechanisms. [PDF]

Neuropsychiatr Dis Treat
Luo Y, Gao X, Shi W, Cheng X, Zhou Y, Wang R, Chen Y.   +6 more
europepmc   +1 more source

ER to: Molecular docking studies on α-amylase inhibitory peptides from milk of different farm animals

Journal of Dairy Science
Priti Mudgil, Mouza Khamis Obaid Al Dhaheri, Maitha Saif Mohammed Alsubousi, Hina Khan, Ali Ali Redha, Pei-Gee Yap, Chee-Yuen Gan, Sajid Maqsood   +7 more
openaire   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate. [PDF]

Chem Biodivers
Tu H, Ding L, Zheng J, Yang Y, Chen X, Song Y, Shi X, Wang C, Xu X, Liu J, Xie Y.   +10 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Biological Activities and In Silico Molecular Docking of an Aqueous Extract of <i>Nigella sativa</i> L. Seeds: A Focus on Antioxidant, Cytotoxic, and Diuretic Effects. [PDF]

Pharmaceuticals (Basel)
Zouirech O, El-Mernissi R, El Hajjaji MA, Takie M, Bouslamti M, Agour A, Alqahtani JH, J Alqahtani M, El Hachlafi N, Miantezila Basilua J, Derwich E.   +10 more
europepmc   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

Comparative Study of the Antioxidant Mediated Antiaging Properties of Endocarp Extracts From <i>Phoenix dactylifera</i> and <i>Phoenix dactylifera L</i>. via In Silico and In Vitro Analysis. [PDF]

Food Sci Nutr
Asaad F, Abbas M, Haider W, Munir N, Zafar MG, Riaz M, Arshad M, Zaman MA, Hussain T, Ayub MA, Ejaz H, Akter QS.   +11 more
europepmc   +1 more source