Results 1 to 10 of about 214,518 (269)

Antimicrobial and Antiproliferative Activities and Enzyme Binding Affinity of Xanthen-3-one Derivatives [PDF]

Kemija u Industriji, 2022
Ten biologically active derivatives of 2,6,7-trihydroxyxanthen-3-one, previously synthesized and characterised, were investigated for their in vitro antimicrobial and antiproliferative activity.
Elma Veljović, Anja Harej, Marko Klobučar, Sandra Kraljević Pavelić, Selma Špirtović-Halilović, Amar Osmanović, Samija Muratović, Mirsada Salihović, Davorka Završnik   +8 more
doaj   +1 more source

Computational Purposing Phytochemicals against Cysteine Protease of Monkeypox Virus: An In-silico Approach

Journal of Pure and Applied Microbiology, 2022
The development and evolution of viruses that cause disease have presented a formidable challenge to contemporary medicine and the global economy, not to mention a catastrophic risk to human health.
Poonam Bansal, Mahiti Gupta, Sonali Sangwan, Gurpreet Kaur Bhatia, Seema Ramniwas, Deepak Chandran, Abhijit Dey, Kuldeep Dhama, Hardeep Singh Tuli   +8 more
doaj   +1 more source

Neuroprotective Drug Discovery From Phytochemicals and Metabolites for CNS Viral Infection: A Systems Biology Approach With Clinical and Imaging Validation

Frontiers in Neuroscience, 2022
BackgroundRecent studies have reported that pulmo-neurotropic viruses can cause systemic invasion leading to acute respiratory failure and neuroinfection.
Anindita Bhattacharjee, Pratik Purohit, Prasun K. Roy   +2 more
doaj   +1 more source

Thioester-Containing Benzoate Derivatives with α-Glucosidase Inhibitory Activity from the Deep-Sea-Derived Fungus Talaromyces indigoticus FS688

Marine Drugs, 2021
Eurothiocins C–H (1–6), six unusual thioester-containing benzoate derivatives, were isolated from the deep-sea-derived fungus Talaromyces indigoticus FS688 together with a known analogue eurothiocin A (7).
Mingqiong Li, Saini Li, Jinhua Hu, Xiaoxia Gao, Yanlin Wang, Zhaoming Liu, Weimin Zhang   +6 more
doaj   +1 more source

Design, synthesis and molecular modeling study of substituted indoline-2-ones and spiro[indole-heterocycles] with potential activity against Gram-positive bacteria

Acta Pharmaceutica, 2022
Longstanding and firsthand infectious diseases are challenging community health threats. A new series of isatin derivatives bearing β-hydroxy ketone, chalcone, or spiro-heterocycle moiety, was synthesized in a good yield.
Radwan Awwad Abdoh, Aanazi Fares Kaed, Al-Agamy Mohammed, Mahrous Gamal Mohammad   +3 more
doaj   +1 more source

Sintesis, Karakterisasi Struktur, dan Kajian Molecular Docking Senyawa Turunan 4’-Metoksi Flavonol sebagai Antagonis Reseptor Estrogen Alpha (ER-a) pada Kanker Payudara

Jurnal Riset Kimia, 2022
A long period of drug administration in breast cancer chemotherapy can cause various side effects. These situations encourage researchers to search for and develop alternative anticancer drugs through various approaches.
Ihsan Ikhtiarudin, Rahma Dona, Neni Frimayanti, Rahayu Utami, Nurul Susianti, Abdi Wira Septama   +5 more
doaj   +1 more source

Evaluation of COVID-19 protease and HIV inhibitors interactions

Acta Pharmaceutica, 2022
The epidemic of the novel coronavirus disease (COVID-19) that started in 2019 has evoked an urgent demand for finding new potential therapeutic agents.
Tran Linh, Tam Dao Ngoc Hien, Elhadad Heba, Hien Nguyen Minh, Huy Nguyen Tien   +4 more
doaj   +1 more source

In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases

Molecules, 2021
In the current study, a simple in silico approach using free software was used with the experimental studies to optimize the antiproliferative activity and predict the potential mechanism of action of pyrrolizine-based Schiff bases. A compound library of
Faisal A. Almalki, Ashraf N. Abdalla, Ahmed M. Shawky, Mahmoud A. El Hassab, Ahmed M. Gouda   +4 more
doaj   +1 more source

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study

Molecules, 2022
Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our research group has synthesized and evaluated libraries of heterocyclic analogs against α-glucosidase and α-amylase enzymes and found encouraging results.
Hayat Ullah, Shoaib Khan, Fazal Rahim, Muhammad Taha, Rashid Iqbal, Maliha Sarfraz, Syed Adnan Ali Shah, Muhammad Sajid, Mohamed F. Awad, Awatif Omran, Marzough Aziz Albalawi, Mahmoud A. Abdelaziz, Azza Al Areefy, Ibrahim Jafri   +13 more
doaj   +1 more source

Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies

Frontiers in Molecular Biosciences, 2020
The research explores the synthesis of a series of novel hybrid quinazolin-2,4-dione analogs bearing acetyl/amide bridged-nitrogen heterocyclic moieties such as azetidinone, pyrrole, oxazole, oxadiazole, thiazole, pyrazole, and thiazolidine scaffolds 2 ...
Aboubakr Haredi Abdelmonsef, Mahmoud Eldeeb Mohamed, Mohamed El-Naggar, Hussain Temairk, Ahmed Mohamed Mosallam   +4 more
doaj   +1 more source