Results 131 to 140 of about 905,868 (291)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Julio Aristegui Villamil: el médico de los pobres

open access: yesRevista Médica Electrónica
RESUMEN Julio Miguel Aristegui Villamil se gradúa de Doctor en Medicina en la Universidad de La Habana en 1929 y regresa a Cárdenas, su ciudad natal, a ejercer su profesión. Sus ideas progresistas lo afilian a la Izquierda Médica, dentro de la Federación
Yovanny Ferrer Lozano   +3 more
doaj  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Impact of health care system on socioeconomic inequalities in doctor use [PDF]

open access: yes
This study examines the impact of health system characteristics on social inequities in health care use in Europe, using data from national surveys in 13 European countries.
Engin Yilmaz, Zeynep Or, Florence Jusot
core  

Doctor Armando Amable Pancorbo Pancorbo. Figura cimera de la Docencia Médica Superior en Matanzas

open access: yesRevista Médica Electrónica
RESUMEN El 6 de enero de 1969 se distingue en la provincia de Matanzas por ser el inicio de la docencia médica superior en la Provincia, al arribar a la misma 32 estudiantes del sexto año de la carrera de medicina, al frente de la vice dirección docente ...
Enrique Armando Pancorbo Sandoval   +3 more
doaj  

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