Results 141 to 150 of about 905,868 (291)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

'Conditions of time and space': a re-enactment experiment with the British TV series Doctor Who.

open access: yes
The aim of this thesis is to provide a contribution to knowledge in two areas. Firstly, it seeks to further our understanding of the historical conditions of British television drama production; in particular the constraining and liberating influences of
Ireland, Andrew
core  

The Doctor in Literature. Volume 4. Gender and Sex [PDF]

open access: yes, 2013
This book is the fourth of four volumes in the series The Doctor in Literature. Like the first three it is intended to serve as an indexed, annotated anthology and to bring together a total of some 1500 extracts from approximately 600 works of fiction ...
Posen, Solomon
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Doctor Watson Architects: Publications in the History & Theory of Architecture

open access: yes, 2018
In order to experiment freely with the possibilities of combining written and visual media in texts about architectural history and theory and the AIR Grid we have set up our own publishing company called Miniminx Publications.
Watson, V.A.
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Doctor Who: A British Alien

open access: yes, 2018
This book argues that Doctor Who, the world’s longest-running science fiction series often considered to be about distant planets and monsters, is in reality just as much about Britain and Britishness.
Nicol, D.
core  

A survey of knowledge about preterm infant interactive communication of medical and nursing staffs in neonatal intensive care unit

open access: yesHuli yanjiu, 2009
Objective:To know the status quo of grasping of knowledge about preterm infant interactive communication of medical and nursing staffs in neonatal intensive care unit (NICU).Methods:A total of 60 doctors and 68 nurses from NICU of 4 third-grade hospitals
赵敏慧, 陈超, 袁浩斌
doaj  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

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