Results 51 to 60 of about 114,817 (266)

Education of pharmacists in Ghana: evolving curriculum, context and practice in the journey from dispensing certificate to doctor of pharmacy certificate

BMC Medical Education, 2020
Background Understanding the origin and evolution of education of pharmacists is important for practice and health system reforms. In Ghana, education of pharmacists started in the 1880s with the training of dispensers in a government hospital.
Augustina Koduah, Irene Kretchy, Reginald Sekyi-Brown, Michelle Asiedu-Danso, Thelma Ohene-Agyei, Mahama Duwiejua   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dr. Packianathan “Chella” Chelladurai: An Eminent Scholar in Sport Management. [Dr. Packianathan “Chella” Chelladurai: Un eminente académico en gestión deportiva]. [PDF]

Revista Internacional de Ciencias del Deporte, 2014
Dr. Packianathan “Chella” Chelladurai has a long and distinguished career in sport management and is a recognized scholar of management science. Chella received his Bachelor’s and Doctor of Physical Education degrees from the University of Madras, India.
Donna L. Pastore
doaj  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

CURRENT DIRECTIONS OF RESEARCH IN INFORMATION- COMMUNICATION TECHNOLOGIES IN THE FIELD OF PEDAGOGICAL SCIENCE.

Ìнформаційні технології в освіті, 2010
In the publication modern research areas of information-communication technologies in pedagogical science are identified. The basic requirements of the new passport for the specialty 13.00.10 - Information and Communication Technologies in Education are ...
O.N. Spirin, A.V. Svietlorusova
doaj  

Impact (s) of Doctoral Degrees Held by Faculty Members in Portuguese Higher Education

Procedia - Social and Behavioral Sciences, 2013
AbstractIn order to verify the impact(s) of doctoral programs processes of faculty members in higher education in Portugal, we applied a questionnaire survey to the completed PhD of teachers. This study is based on a questionnaire survey to the doctoral degrees of faculty members in Portuguese higher education, completed between 2007 and 2012, the ...
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

REFORMING THE EUROPEAN DOCTORAL EDUCATION SYSTEM IN THE CONTEXT OF FORMATION OF GENERIC COMPETENCES [PDF]

Alfred Nobel University Journal of Pedagogy and Psychology
The article analyses the EU regulatory and recommendatory documents which manage the process of reforming the doctoral education system in the context of formation of generic (universal) competences. The problem of improving the higher education system,
Derstuganova Natalia
doaj   +1 more source