Results 81 to 90 of about 1,132,182 (312)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

REFORMING THE EUROPEAN DOCTORAL EDUCATION SYSTEM IN THE CONTEXT OF FORMATION OF GENERIC COMPETENCES [PDF]

Alfred Nobel University Journal of Pedagogy and Psychology
The article analyses the EU regulatory and recommendatory documents which manage the process of reforming the doctoral education system in the context of formation of generic (universal) competences. The problem of improving the higher education system,
Derstuganova Natalia
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The content of the formation of linguistic competence of students of medical universities

Вестник Самарского университета: История, педагогика, филология
The aim of the article is to consider the peculiarities of studying linguistic disciplines by medical students. Special attention is paid to determining the degree of importance of communicative skills of a doctor from the point of view of modern ...
T. F. Izvekova, Yu. S. Toryanik
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Scholarship of Research Degrees: Influential Publications and Influential Writers in the Discipline of Doctoral Education

SSRN Electronic Journal, 2020
The results of a survey of the international community of scholars and professionals involved in the practice and study of doctoral education are reported. Its purpose was to identify the most influential publications in the discipline and its most influential writers. The use of citation analysis as a method is discussed, and the reasons for rejecting
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Health Information Online [PDF]

, 2005
Presents findings from a survey conducted in November 2004. Looks at the growth in Internet use for finding health information; the specific health topics that are most frequently searched; and trends that are likely to influence online health ...
Susannah Fox
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach [PDF]

, 2019
In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the ...
Abdullina, L. B. (L), Babieva, N. S. (N), Golovneva, E. V. (E), Kanbekova, R. V. (R), Khvostunov, K. O. (K), Madzhuga, A. G. (A), Moskvina, A. V. (A), Salimova, R. M. (R), Sokolskaya, M. V. (M)   +8 more
core   +3 more sources