Results 91 to 100 of about 166,973,685 (275)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

From vision to reality, transforming PK-12 education in Ohio

, 2008
Electronic coverage as of Dec. 23, 2009: 2006/2007-; Some reports also have a distinctive title.; Latest issue consulted: 2007/2008.; Description based on: 2006/2007; title from PDF cover (viewed on Dec. 23, 2009)
Ohio. State Board of Education.
core  

The impact of outdoor education on executive function in adolescents [PDF]

, 2020
This mixed-methods study investigated the nature of the impact of a multi-day outdoor education camp on the executive functions of sixth grade students (n = 29) in Alberta, Canada.
McKenzie, Jared Patrick, University of Lethbridge. Faculty of Education.   +1 more
core  

HIGHER EDUCATION STANDARDS FOR THE THIRD (EDUCATIONAL AND SCIENTIFIC) LEVEL OF HIGHER EDUCATION IN THE FIELD OF KNOWLEDGE “EDUCATION”: ANALYSIS OF THE LIST OF COMPULSORY GENERAL COMPETENCIES

Проблеми інженерно-педагогічної освіти
DOI: https://doi.org/10.26565/2074-8922-2025-84-01 Reforming the higher education system of Ukraine and its orientation towards the best international practices involves the introduction of a new approach to assessing the quality of educational ...
N. V. DERSTUGANOVA
doaj  

Availability, Uniqueness and Perceived Value of Bachelor of Science in Pharmaceutical Sciences (BSPS) Programs in the United States

Pharmacy, 2013
We describe the uniqueness of the Bachelor of Science in Pharmaceutical Sciences (BSPS) degree and the factors that contribute to this uniqueness. A total of 18 colleges and schools that offer a BSPS were identified in the literature and compared.
Rabaa M. Al-Rousan, Fadi M. Alkhateeb, Michael Veronin, David A. Latif, Marea Dodd   +4 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

The Stateless Legal Clinic: Innovative Models for Addressing Unmet Legal Need in Australia through Clinical Legal Education

International Journal of Clinical Legal Education
The Stateless Legal Clinic is a unique service providing legal education and aid to eligible stateless children in their application for Australian citizenship.
Katie Robertson
doaj   +1 more source