Results 111 to 120 of about 3,488,731 (283)
Advanced Science, EarlyView.Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi +10 more
wiley +1 more source
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Quantitative Stain Mapping in X‐Ray Virtual Histology
Advanced Science, EarlyView.Virtual histology promises 3D tissue examination without physical sectioning, yet has lacked the tissue‐specificity of conventional pathology. This work demonstrates the first quantitative three‐dimensional stain mapping at histologically relevant resolution, separating contrast agent from tissue to reveal cellular features such as nuclei. The approach
Dominik John +16 more
wiley +1 more source
Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI
Advanced Science, EarlyView.ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia +7 more
wiley +1 more source
Doctoral students’ research motivation and outcomes in China: training environment moderation
Cogent EducationThe exploration of factors influencing the output of doctoral research results is meaningful for higher education management. This study’s purpose lay in investigating the influence of motivation and training environment on doctoral students’ research ...
Siqi Huang, Cheng-Cheng Yang
doaj +1 more source
Advanced Science, EarlyView.Inspired by the regulation mechanism of window blinds, this study designs an electromagnetic wave‐absorbing metamaterial. By introducing the magneto‐electric coupling concept and integrating it with an artificial intelligence‐based data‐driven collaborative optimization strategy, the material optimizes impedance matching performance and enhances loss ...
Zhe Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling +17 more
wiley +1 more source