Results 51 to 60 of about 36,414 (242)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

BUILDing pathways to health-related research careers in biomedical and behavioral sciences: a longitudinal evaluation of postbaccalaureate outcomes using a matched comparison group

Frontiers in Education
The BUilding Infrastructure Leading to Diversity (BUILD) undergraduate research training program is funded by the National Institutes of Health (NIH) to strengthen the pipeline for underrepresented students through graduate school and into health-related
Erin H. Arruda, Kim-Phuong L. Vu, Chi-Ah Chun, Gino Galvez, Panadda Marayong, Jesse G. Dillon   +5 more
doaj   +1 more source

Community-Based Mangrove Forest Development as an Ecotourism Area to Improve Community Welfare [PDF]

E3S Web of Conferences
This study aims to examine and improve the potential of mangrove forests in Teluk Pambang and Selat Baru, Bengkalis Indonesia to improve community welfare.
Elfina Yetti, Sukendi Sukendi, Efriyeldi Efriyeldi, Sutikno Agus, Syahza Almasdi   +4 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The policy framework for international collaborative programmes: Perpetuating outdated prescriptions for joint and double degrees?

South African Journal of Science
The Policy Framework on the Internationalisation of Higher Education in South Africa (PF) acknowledges the strategic priority of international research collaboration for the country, and the role of cross-border and collaborative provision of higher ...
Dorothy Stevens, Liezel Frick
doaj   +1 more source

Stability and Longevity in the Publication Careers of U.S. Doctorate Recipients.

PLoS ONE, 2016
Since the 1950s, the number of doctorate recipients has risen dramatically in the United States. In this paper, we investigate whether the longevity of doctorate recipients' publication careers has changed.
Cathelijn J F Waaijer, Benoît Macaluso, Cassidy R Sugimoto, Vincent Larivière   +3 more
doaj   +1 more source

TO BE A DOCTOR. [PDF]

JAMA: The Journal of the American Medical Association, 1896
Of all callings, medicine and surgery seems to me the noblest. What occupation can be more elevating to its followers, or more benificial to mankind, than the alleviating of human suffering? The work is hard and the pay none too good; but the life of a medical man is active and stirring, and both the study and practice of the science have a singular ...
openaire   +1 more source