Results 51 to 60 of about 402,125 (283)

Entrepreneurship and UK doctoral graduates [PDF]

open access: yes, 2011
Copyright c 2011 IP Publishing Ltd. Reproduced by permissionThis paper discusses the experience of UK doctoral graduates in pursuing entrepreneurial careers: there is evidence that this applies to a substantial number - about 10% - of doctoral graduates.
Bentley, Kieran   +2 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Benefits and pitfalls of scientific research during undergraduate medical education [Nutzen und Stolpersteine wissenschaftlicher Forschung in der hochschulmedizinischen Ausbildung]

open access: yesGMS Zeitschrift für Medizinische Ausbildung, 2010
[english] Objective: The integration of scientific research into medical education is a widely discussed topic. Most research training programs are offered on a voluntary basis.
Kuhnigk, Olaf   +7 more
doaj   +1 more source

Doctorateness: where should we look for evidence? [PDF]

open access: yes, 2017
This chapter considers the possibility of an “institutional theory of artistic research”. It proposes four distinct quadrants in which one might look for evidence for such a theory, which needs to have the capacity to accommodate the diverse positions on
Biggs, Michael
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

John Windmuller [PDF]

open access: yes, 2004
[Excerpt] John Windmuller received his doctorate in industrial and labor relations from Cornell in 1951-one of the first granted by the school-the same year he was appointed to the ILR School faculty. In 1983 he was named the Martin P.

core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Advanced periodic maintenance scheduling methods for aircraft lifecycle management [PDF]

open access: yes, 2013
This paper reviews existing methods and techniques addressing the problem of maintenance support throughout the life cycle for high value manufacturing products such as aircrafts.
Fedotova, Alena   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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