Results 81 to 90 of about 575,094 (228)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Implementation of entrustable professional activities for interns within the new Australian National Framework: a pilot study using action-research to explore utility, and clarify challenges and enablers

BMC Medical Education
Background Programs worldwide are introducing programmatic assessment and Entrustable Professional Activities (EPAs) with strong theoretical foundations and growing research evidence regarding potential benefits.
Christina E Johnson, Ambika Wakhlu, Victor Au Yeung, Sarah Meiklejohn, Rory McCarthy, Stephanie Snedden, Jason R Frank, Brendan Crotty, Lambert WT Schuwirth, Damian J Castanelli, Andrea Bramley   +10 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Digital health for Tuberculosis control: findings from the piloting of an electronic medical record in Luanda (Angola)

BMC Medical Informatics and Decision Making
Background Digital health, like the use of electronic medical records (EMR), has been highlighted as a potential avenue to improve Tuberculosis (TB) surveillance and treatment outcomes.
Claudia Robbiati, Maria Elena Tosti, Joaquim Tomas, Giulia Natali, Luca De Simeis, Nsuka Da Silva, Florentino Ferraz Joaquim, Daniel Tulomba, Neusa Lazary, Janet Adão, Fabio Manenti, Maria Grazia Dente   +11 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Effectiveness of Bundled Interventions for the Prevention of Neonatal Hypothermia in Low-Income Settings: A Quality Improvement Project in a Referral Hospital in Ethiopia

Children
Background: Hypothermia at admission and in the following days is a major risk factor for neonatal mortality in both high- and low-resource settings.
Margherita Baracetti, Eleni Hagos, Jiksa Tolera, Francesco Cavallin, Enzo Facci, Giovanni Putoto, Fabio Manenti, Daniele Trevisanuto, Andrea Pietravalle   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

P71 High hepatitis C cure rate in a general practice cohort

Journal of Virus Eradication, 2017
D. Baker, M. McMurchie, C. Rodgers, V. Farr, M. Williams, L. Williams   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source