Results 71 to 80 of about 567,473 (231)

Measuring preparedness to infectious diseases among people exposed to climate disasters in Cabo Delgado, Mozambique: a cross-sectional study

BMC Public Health
Introduction Climate change is contributing to increase the frequency and severity of climate disasters in Mozambique, leading, since 2019, to extensive damage to infrastructure and displacement 1.3 million people.
Francesco Vladimiro Segala, Edoardo Occa, Elsa Chambisse, Francesco Cavallin, Agostinho Nanomba, Rumela Cobre, Giorgia Gelfi, Vitor Laguessa, Simone Cadorin, Abdul Chorai, Ketan Chitnis, Claudia Marotta, Inusso Chuau, Angelo Ghelardi, Aida Mahomed, Giovanni Putoto, Manuel Aly Mussa, Annalisa Saracino, Francesco Di Gennaro   +18 more
doaj   +1 more source

Clinical and Radiographic Predictors of Deterioration in Mild Cervical Spondylotic Myelopathy

Philippine Journal of Orthopaedics
Background and Objectives. The management approach for mild cervical spondylotic myelopathy (CSM) is still unclear, and the decision to perform outright surgery remains a topic of debate.
Jose Kreisher Rae Foscablo, John David Mata, Immanuel Silverio, Ronald Tangente   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Letter to the Occupy Movement: Freeing Our Physicians

Social Medicine, 2012
Open letter from members of Doctors for the 99% and Healthcare for the 99% to the greater Occupy community.
Noriyuki Murakami, Amit Patel, Magni Hamso, Avra Ackerman   +3 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Digital health for Tuberculosis control: findings from the piloting of an electronic medical record in Luanda (Angola)

BMC Medical Informatics and Decision Making
Background Digital health, like the use of electronic medical records (EMR), has been highlighted as a potential avenue to improve Tuberculosis (TB) surveillance and treatment outcomes.
Claudia Robbiati, Maria Elena Tosti, Joaquim Tomas, Giulia Natali, Luca De Simeis, Nsuka Da Silva, Florentino Ferraz Joaquim, Daniel Tulomba, Neusa Lazary, Janet Adão, Fabio Manenti, Maria Grazia Dente   +11 more
doaj   +1 more source

Effectiveness of Bundled Interventions for the Prevention of Neonatal Hypothermia in Low-Income Settings: A Quality Improvement Project in a Referral Hospital in Ethiopia

Children
Background: Hypothermia at admission and in the following days is a major risk factor for neonatal mortality in both high- and low-resource settings.
Margherita Baracetti, Eleni Hagos, Jiksa Tolera, Francesco Cavallin, Enzo Facci, Giovanni Putoto, Fabio Manenti, Daniele Trevisanuto, Andrea Pietravalle   +8 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source