Results 101 to 110 of about 205,748 (286)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
University of Twente at the TREC 2007 Enterprise Track : modeling relevance propagation for the expert search task [PDF]
, 2007 This paper describes several approaches which we used for the expert search task of the TREC 2007 Enterprise track.\ud We studied several methods of relevance propagation from documents to related candidate experts.
Hiemstra, Djoerd +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Humanities & Social Sciences CommunicationsIn this paper, we critically examine the 2022 UK Digital Strategy and argue that the UK government adopts with this policy document a customer-centric vision of governance, which undermines the traditional role of the government as a provider of public ...
Efpraxia D. Zamani, Anastasia Rousaki
doaj +1 more source
Impact of Servitized Corporate Models in Providing A Competitive Edge to The Manufacturing Industry
JTRMThis document reviews the impact of servitization on manufacturing companies' corporate models. It discusses how product-centric firms can transition to service-oriented models by incorporating software services into their offerings.
S M Nazmuz Sakib
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Software knowledge graph construction and Q＆amp;A technology based on big data
大数据, 2021 With the increasing of software scale and software evolution, it is more and more important to construct software project knowledge graph for software maintenance and software development.
Yanzhen ZOU +3 more
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Frontiers in Political ScienceThis study examines the integration of artificial intelligence (AI) into the processing of Synthetic Aperture Radar (SAR) imagery by the Brazilian Air Force to strengthen the strategic monitoring of the Amazon.
Gabriela Alves de Borba Costa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source