Results 111 to 120 of about 205,748 (286)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Health Research Policy and SystemsMost forms of clinical research examine a very minute cross section of the patient journey. Much of the knowledge and evidence base driving current genomic medicine practice entails blind spots arising from underrepresentation and lack of research ...
Patrick J. Silva +9 more
doaj +1 more source
Database independent Migration of Objects into an Object-Relational Database [PDF]
, 2002 This paper reports on the CERN-based WISDOM project which is studying the serialisation and deserialisation of data to/from an object database (objectivity) and ORACLE 9i.Comment: 26 pages, 18 figures; CMS CERN Conference Report ...
Ali, Arshad +4 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Framing Experience: Concept Maps, Mind Maps, and Data Collection in Qualitative Research
International Journal of Qualitative Methods, 2009 Traditionally, qualitative data collection has focused on observation, interviews, and document or artifact review. Building on earlier work on concept mapping in the social sciences, the authors describe its use in an exploratory pilot study on the ...
Johannes Wheeldon, Jacqueline Faubert
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
SOME CONCEPTUAL PROPERTIES FOR KNOWLEDGE MANAGEMENT SYSTEMS DESIGN [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2005 Knowledge Management Systems (KMS) are important tools by which organizations can better useinformation and, more importantly, manage knowledge. Unlike other strategies, knowledge management (KM) isdifficult to define because it encompasses a range of ...
Vasile MAZILESCU
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source