Results 91 to 100 of about 4,688,083 (288)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The importance of preventive conservation in the history of the conservation and restoration of cultural property

, 2018
Se muestra un proyecto puesto en marcha en el marco docente de la asignatura Teoría e Historia de la Conservación y Restauración de Bienes Culturales del Grado de Conservación y Restauración de la Facultad de Bellas Artes de la Universidad de Sevilla ...
Ruiz-de-Lacanal, María-Dolores, Medina Castell, Eva M., Hernández Romero, Carlos Manuel, International Institute for Conservation of Historic and Artistic Works (Coordinador), Serrano Larrea, Carmen   +4 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Freehold Soil Conservation District Conservation Connection Fall 2008

, 2008
This newsletter from the Freehold Soil Conservation District contains the following articles: Three Scholarships Awarded; Trout Release Day; Stormwater BMPs for Construction Sites; Jersey Fresh Recipe Cards Available; Patterson Joins Board; Staff News ...

core   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Document Management focused on Preventive Conservation of Documents

, 2017
La gestión documental enfocada en la conservación de documentos minimiza los perjuicios que se pueden generar en las instituciones por la pérdida o extravío. En este estudio se muestran los aspectos relativos a la gestión documental desde la conservación preventiva de documentos.
Paz Enrique, Luis Ernesto, Hernández Alfonso, Eduardo Alejandro   +1 more
openaire   +1 more source

Civilian Conservation Corps (U.S.). Shenandoah Park (Va.) Photographs, 1934-1936

, 1934
The photographs document CCC members of camps 2, 4 and 5 working on the Skyline Drive, Shenandoah Valley, Virginia. Included are group photographs of CCC members, camps and other outdoor scenes, and other scenes.

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Conservation Connection: Freehold Soil Conservation District Newsletter, Fall 2007

, 2007
This newsletter from the Freehold Soil Conservation District contains the following articles: Trout in the Classroom 2007; William "Bill" Schauer 1929-2007; 2008 Poster Contest: Water is Life; 2008 Envirothon for High School Students; Buscaglia Named ...

core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Ohio's Agriculture Pollution Abatement Program protecting our soil and water resources

, 2006
Title from PDF p. [1] (viewed on Jan. 30, 2007).; "This brochure was created by the staff of the Geauga Soil and Water Conservation District under the authority of the Board of Supervisors ..."; "Created: 8/2/2006 ..."--Document properties.; Brochure ...
Geauga Soil and Water Conservation District (Ohio)
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