Results 91 to 100 of about 12,924,830 (244)
Constructing the future of design : How design professionals perceive their changing role
, 2018 Design and design thinking have boomed in the past decade, expanding design considerations into new areas of application and a wide range of organizations across industry types.
Björklund, Tua A. +2 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Zhongguo yiliao qixie zazhiObjectiveTo reduce the variability in detection results and enhance the stability of product quality in fully automated flow fluorescence immunoassay analyzers by introducing robust parameter design.
Yunhe LI +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Design and Evaluation of a Low-Code/No-Code Document Management and Approval System
InformationThis paper presents the design, implementation, and evaluation of a low-code document management and approval system developed on the Microsoft Power Platform.
Constantin Viorel Marian +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Call for Papers for the 1973 Design Activity International Conference
, 1973 The 1973 Design Research Society Conference was held jointly with the US Design Methods Group on 29-31 August 1973 at The Polytechnic of Central London.
Design Research Society and Design Methods Group,
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
, 2017 The present study investigates what skill set employers expect from graphic designers, based on a document analysis of 1,406 job advertisements from the United Kingdom. In organising the statements made in the advertisements, we describe the skill set of
Person, Oscar +1 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source