Results 71 to 80 of about 12,924,830 (244)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Surfing for Inspiration: digital inspirational material in design practice [PDF]

open access: yes, 2018
Over the last decade, many new opportunities have emerged to support creativity and problem-solving in design by finding inspirational materials via the Internet.
Laszlo, Magda   +8 more
core   +1 more source

Inclusivity, Gestalt Principles, and Plain Language in Document Design

open access: yesIn the Library with the Lead Pipe, 2016
In Brief: Good design makes documents easier to use, helps documents stand out from other pieces of information, and lends credibility to document creators.
Jennifer Turner, Jessica Schomberg
doaj  

Sustainable Community Development Step 3: Create a Community Vision and Develop a Roadmap

open access: yesEDIS, 2003
This document presents information on developing a design to create a sustainable community. The design process, also known as a charrette, is divided into three parts. This document also includes a community planning visioning exercise.
Mickie E. Swisher   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Design and information technology

open access: yes, 1984
6.75; Design Policy no. 6SIGLEAvailable from British Library Document Supply Centre- DSC:GPB-4524 / BLDSC - British Library Document Supply CentreGBUnited ...
Design Research Society, London (United Kingdom)   +2 more
core  

Interpretations of design thinking across a large organization

open access: yes, 2019
Design thinking has a prominent role as established corporations ramp up innovation efforts focusing on user needs. Current literature provides a plethora of definitions for design thinking with variations in tools, methods and cultures.
Björklund, Tua   +2 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Il ruolo del design nella progettazione alberghiera

open access: yes, 2014
l'autore è stato invitato a stendere un contributo sul ruolo del design nell'ambito della progettazione alberghiera, evidenziando le varie declinazioni della disciplina- design strategico, design dei servizi, design della comunicazione, interior design,
SCULLICA, FRANCESCO   +1 more
core  

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