Results 61 to 70 of about 12,924,830 (244)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Nature and role of intermediate representation (IR) in the design process [PDF]
, 2005 This paper aims to show the key role of the intermediate representations (IR) in the design process and especially in the car design process. For a better understanding of the concept of design, which is by nature conceptual, we propose to study the ...
AOUSSAT, Améziane +2 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
L’exposition au design : Amorcer la pratique du design par la documentalisation des objets
Interfaces Numériques, 2019 L’article analyse une expérimentation d’exposition au design réalisée par trois membres du Collectif de design pointhuit et menée au Carrefour numérique2 de la Cité des sciences et de l’industrie avec la participation de l’un des co-auteurs. L’exposition
Dorian Reunkrilerk, Annie Gentès
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Making the design documentation for printed circuit boards in a computer-aided design and pre-production [PDF]
Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2007 The paper presents an approach to the design of drawings of printed circuit boards, which allows to significantly simplify documentation and streamline the document management.
Efimenko A. A. +2 more
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2018 How to practically monitor what is sought from designers in practice forms a basic concern for educators in design. In this paper, we analyse what employers require from applicants in 230 job advertisements for graphic design positions from Finland.
Person, Oscar +5 more
core +1 more source
Lexikos, 2011 <p>Abstract: Although recent dictionaries for the ESL market have been praised for their innovative design features, the prime concern of users, lexicographers and metalexicographers is the functional quality of the dictionary products provided for
Piet Swanepoel
doaj +1 more source