Results 91 to 100 of about 6,614,488 (283)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Identifying features of risk periods for suicide attempts using document frequency and language use in electronic health records. [PDF]
Front Psychiatry, 2023 Dutta R +6 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
2009 Self-Study Document [PDF]
, 2009 The University self study completed for the university\u27s last HLC reaccreditation process in 2009. Following the criteria then put forward for HLC accreditation, this comprehensive document gives a detailed picture of where the university was ten ...
Higher Learning Commission document
core
The Living Document : Medical Records as a Malleable Presence [PDF]
Understanding why individuals might safeguard information or keep secrets in working documents such as medical records is essential for the development of good quality care, fostering an environment where both patients and staff feel secure to part with ...
Lyckblad, Camilla
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Parabolic Weighting Mechanism in Information Retrieval: A Mathematical Analogy to Lenz’s Law
IEEE AccessConventional term-weighting techniques in information retrieval, such as term frequency-inverse document frequency and the probabilistic ranking framework, often place excessive emphasis on extreme term frequencies, which can distort document ranking ...
Krishnan Batri +2 more
doaj +1 more source
DocDeshadower: Frequency-Aware Transformer for Document Shadow Removal
2024 IEEE International Conference on Systems, Man, and Cybernetics (SMC)Shadows in scanned documents pose significant challenges for document analysis and recognition tasks due to their negative impact on visual quality and readability. Current shadow removal techniques, including traditional methods and deep learning approaches, face limitations in handling varying shadow intensities and preserving document details.
Ziyang Zhou 0001 +6 more
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source