Results 121 to 130 of about 6,614,488 (283)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Proactive Detection of Malicious Webpages Using Hybrid Natural Language Processing and Ensemble Learning Techniques

Journal of Information and Organizational Sciences
The proliferation of malicious webpages presents a growing threat to online security, necessitating advanced detection methods to mitigate risks. This paper proposes a novel approach that integrates Natural Language Processing (NLP) techniques with an ...
Althaf Ali A, Rama Devi K, Syed Siraj Ahmed N, Ramchandran P, Parvathi S   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Optimizing Support Vector Machine (SVM) for Sentiment Analysis of Blu by BCA Reviews with Chi-Square

Journal of Applied Informatics and Computing
One of the products resulting from the development of financial technology is the blu by BCA application. This app can be downloaded by BCA bank users via the Google Play Store and has received various user responses in the form of reviews.
Aldi Widodo, Bambang Agus Herlambang, Ramadhan Renaldy   +2 more
doaj   +1 more source

Low Frequency Ultrasonic Voice Activity Detection using Convolutional Neural Networks [PDF]

Low frequency ultrasonic mouth state detection uses reflected audio chirps from the face in the region of the mouth to determine lip state, whether open, closed or partially open.
Song, Yan, McLoughlin, Ian Vince
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Regional document supply networks and their influence on national document supply networks in China [PDF]

, 2014
Purpose - This paper aims to describe typical regional document supply networks in China through detailed discussion of their framework, service mode and influence on the nationwide document supply networks.
Wei Yang, 杨薇, Yongxin Gao, 高永欣
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The Impact of Electronic Journals on Document Delivery Services [PDF]

, 2006
Collection management policies of libraries were mainly shaped by in-house use of materials in the past. Yet the emergence of electronic journals and their availability through publishers’ or aggregators’ web sites is changing this practice considerably.
Ünal, Yurdagül, Tonta, Yaşar
core   +1 more source

Implementasi Metode Term Frequency-Inverse Document Frequency -Class Frequency Untuk Peringkasan Berita Online

, 2017
Penelitian ini bertujuan untuk meningkatkan dan mengimplementasikan Metode Term Frequency Inverse Document Frequency dengan metode Class Frequency pada peringkasan berita online.
Juhar
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