Results 101 to 110 of about 15,930,327 (280)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Npix2Cpix: A GAN-Based Image-to-Image Translation Network With Retrieval- Classification Integration for Watermark Retrieval From Historical Document Images

IEEE Access
The identification and restoration of ancient watermarks have long been a major topic in codicology and history. Classifying historical documents based on watermarks is challenging due to their diversity, noisy samples, multiple representation modes, and
Utsab Saha, Sawradip Saha, Shaikh Anowarul Fattah, Mohammad Saquib   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Remote Assistance for Bone-Fractured Patients using Deep Learning Models

Applied Artificial Intelligence
Remote diagnosis enables healthcare professionals to evaluate and diagnose patients from a distance using telecommunication technologies, enhancing healthcare delivery by improving accessibility, especially for those in remote or underserved areas.
Nallakaruppan Kailasanathan, Sivaramakrishnan Somayaji, Mohamed Baza, Gautam Srivastava, SenthilKumaran Ulaganathan, Gokul Yenduri, Vaishali Ravindranath, Maazen Alsabaan   +7 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Revolutionizing Historical Manuscript Analysis: A Deep Learning Approach with Intelligent Feature Extraction for Script Classification

Acta Informatica Pragensia
The automated classification of historical document scripts holds profound implications for historians, providing unprecedented insights into the contexts of ancient manuscripts.
Merouane Boudraa, Akram Bennour, Tahar Mekhaznia, Abdulrahman Alqarafi, Rashiq Rafiq Marie, Mohammed Al-Sarem, Ayush Dogra   +6 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Deep Learning-Based Detection of One and Two-Column Textual Blocks in Camera-Captured Pashto Documents Images

IEEE Access
The paper explores the layout analysis and classification task of Pashto document images, a field with limited research due to the language’s low-resource status.
Badshah Saeed, Siraj Muhammad, Khalil Ullah, Abdallah Namoun, Ahmad Khan, Ikram Syed, Syed Sajid Ullah, Ibrar Hussain   +7 more
doaj   +1 more source