Results 41 to 50 of about 304,844 (261)

Digitalization Of Document Management System In Medical Organizations: Theoretical Aspect

Здоровье мегаполиса
Introduction. Modern medical organizations, multifunctional medical centers, public and private medical institutions actively use digital technologies such as document management systems to optimize internal business processes and increase the efficiency.
T. V. Baranova
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparative analysis of traditional and automated financial management methods

Путеводитель предпринимателя
The article examines the problems of using traditional and automated methods of financial management, the relevance of which is due to the rapid digital transformation, which creates the need to rethink the methodological foundations.
E. A. Frolov
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Optimization Problems of Document Processing Management

Кібернетика та комп'ютерні технології, 2020
Introduction. The use of various cloud services is becoming an integral part of modern life. At the same time, the owners of such services usually are not going to inform users with the theoretical foundations of the deployment and provision of these ...
Yu.P. Laptin, T.O. Bardadym, A.V. Lefterov   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Document Management in Local Governments: The Principle of Organization and Optimization Methods on the Example of the Municipal District Administration

RUDN Journal of Public Administration
The article discusses the organization of work with documents in a local government body on the example of the administration of the Perelyubsky municipal district of the Saratov region.
Artyom A. Berkaliev, Darya N. Kovaleva
doaj   +1 more source

Diagnostics of the Enterprise Participation in Electronic Public Procurement: the Aspect of Logistics Management [PDF]

Problemi Ekonomiki, 2017
The aim of the article is to formulate and develop the theoretical and methodological foundations for the functioning of the electronic public procurement system in the logistic environment and develop an approach to determining the level of enterprise ...
Klyuvak Oksana V.
doaj  

Patrimonial bureaus procedures of the landlord farms in Russia during the second half of the 19th - early 20th century: the documentation structure

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2019
The relevance of the study lies in the insufficient development in the domestic historiography of the problem of patrimonial bureau procedures in landlords farms, and the need to consider the features of a large market economy with the possibility of ...
R. M. Zhitin, A. G. Topilskiy
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source