Results 101 to 110 of about 4,153,024 (248)

L'administració electrònica i la gestió de documents

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2003
Els projectes d’administració electrònica són actualment el principal factor de canvi de les organitzacions públiques. Aquest canvi, que es pot considerar imparable, té implicacions importants pel que fa a la gestió i la conservació dels documents ...
Serra, Jordi
doaj  

Platformization of research data infrastructure: A decadal analysis of scientific data management plans

Big Data & Society
New federal research policies support data-driven science by requiring data management planning and data preservation for open access to scientific data and research products.
Amelia Acker, Thomas Struett, Yubing Tian, Megan Finn   +3 more
doaj   +1 more source

IIPC Preservation Working Group Report to IIPC Steering Committee

, 2007
This report summarizes the formation of the Preservation Workgroup and its work conducted between June to December ...
International Internet Preservation Consortium. Preservation Working Group
core  

Trustworthy 100-Year Digital Objects: Evidence Even After Every Witness is Dead

, 2003
How can a publisher store digital information so that any reader can reliably test its authenticity, even years later when no witness can vouch for its validity?
Gladney, H.M.
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Indexing clinical documents for long-term preservation through an international coding system

JLIS.it
This paper describes the experience of mapping the document types defined by Medas company, a Digital Preservation Organization for healthcare institutions, to the Logical Observation Identifiers Names and Codes (LOINC) international standard, and ...
Erika Pasceri, Maria Teresa Chiaravalloti   +1 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source