Results 151 to 160 of about 6,834,762 (337)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Searching for the biggest and the brightest; Selection of documents in VR-VIBE [PDF]
, 1997 Elizabeth F. Churchill +3 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Economic Selection Indices: The Best Tool for Dairy Cattle Selection
EDIS, 2019 An economic selection index combines multiple traits into a single value, facilitating the identification of the best animals. This new 3-page document discusses economic selection indices, their changes in the US, and a 2018 update.
Francisco Peñagaricano
doaj
Entropic selection of concepts unveils hidden topics in documents corpora [PDF]
, 2017 Andrea Martini +2 more
openalex +1 more source
Rudolf Dvořák’s Stay in Leipzig and Munich in the Light of Correspondence with Vojta Náprstek: a Selection of Documents [PDF]
, 2021 Ondřej Crhák
openalex +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source