Results 81 to 90 of about 1,802,735 (277)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Customizing Feature Decision Fusion Model using Information Gain, Chi-Square and Ordered Weighted Averaging for Text Classification

open access: yesInternational Journal of Information and Communication Technology Research, 2011
Automatic classification of text data has been one of important research topics during recent decades. In this research, a new model based on data fusion techniques is introduced which is used for improving text classification effectiveness.
Mohammad Ali Ghaderi   +3 more
doaj  

Evaluation of Fingerprint Selection Algorithms for Local Text Reuse Detection

open access: yesApplied Computer Systems, 2020
Detection of local text reuse is central to a variety of applications, including plagiarism detection, origin detection, and information flow analysis.
Jēkabsons Gints
doaj   +1 more source

Thematic Annotation: extracting concepts out of documents [PDF]

open access: yes, 2004
Contrarily to standard approaches to topic annotation, the technique used in this work does not centrally rely on some sort of -- possibly statistical -- keyword extraction. In fact, the proposed annotation algorithm uses a large scale semantic database -
Andrews, Pierre, Rajman, Martin
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

What drives euro area break-even inflation rates? [PDF]

open access: yes
The yield spread between nominal and inflation-linked bonds (or break-even inflation rates, BEIR) is a fundamental indicator of inflation expectations (and associated premia).
Ciccarelli, Matteo, García, Juan Angel
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Adverse Selection in the Market for Slaves in Mauritius, 1825-1835 [PDF]

open access: yes
Evidence on adverse selection in slave markets remains inconclusive. We study this question through notarial acts on public slave auctions in Mauritius between 1825 and 1835, involving 4,286 slaves. In addition to slave characteristics, the acts document
Désiré Vencatachellum   +2 more
core  

Guidelines for the Use of Synthetic Fluid Dust Control Palliatives on Unpaved Roads [PDF]

open access: yes, 2017
The amount of small soil particles, dust, lost from typical unpaved roads to fugitive dust is staggering. A 1 km stretch of unpaved road can contribute over 2400 kg of dust to the atmosphere (4.2 ton/mile) in a typical 3-month summer season.
Barnes, David, Connor, Billy
core  

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