Results 71 to 80 of about 1,380,887 (296)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Supporting process reuse in PROMENADE [PDF]
, 2002 Process reuse (the ability to construct new processes by assembling already built ones) and process harvesting (the ability to build generic processes that may be further reused, from existing ones) are two crucial issues in process technology.
Franch Gutiérrez, Javier +1 more
core +1 more source
The Architecture of MEG Simulation and Analysis Software
, 2011 MEG (Mu to Electron Gamma) is an experiment dedicated to search for the $\mu^+ \rightarrow e^+\gamma$ decay that is strongly suppressed in the Standard Model but predicted in several Super Symmetric extensions of it at an accessible rate.
G. Corti +5 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Methods and costs associated with outfitting light aircraft for remote sensing applications [PDF]
This document was designed to provide the potential user of a light aircraft remote sensor platform/data gathering system with general information on aircraft definition, implementation complexity, costs, scheduling and operational factors involved in ...
Rhodes, O. L., Zetka, E. F.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Formal Properties of XML Grammars and Languages
, 2000 XML documents are described by a document type definition (DTD). An XML-grammar is a formal grammar that captures the syntactic features of a DTD. We investigate properties of this family of grammars.
Berstel, Jean, Boasson, Luc
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A Review of Text Watermarking: Theory, Methods, and Applications
IEEE Access, 2018 During the recent years, the issue of preserving the integrity of digital text has become a focus of interest in the transmission of online content on the Internet. Watermarking has a useful tool in the protection of digital text content as it solves the
Nurul Shamimi Kamaruddin +3 more
doaj +1 more source