Results 151 to 160 of about 16,255,401 (402)

Inclusivity, Gestalt Principles, and Plain Language in Document Design

open access: yesIn the Library with the Lead Pipe, 2016
In Brief: Good design makes documents easier to use, helps documents stand out from other pieces of information, and lends credibility to document creators.
Jennifer Turner, Jessica Schomberg
doaj  

Ilex decidua 'Hunter' Hunter Possumhaw

open access: yesEDIS, 2007
This document provides a detailed overview of the ‘Hunter’ possumhaw (Ilex decidua ‘Hunter’), a native North American shrub or small tree. It describes the plant’s physical characteristics, including its height, spread, leaf arrangement, and fruiting ...
Edward Gilman
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

TextDoctor: Unified Document Image Inpainting via Patch Pyramid Diffusion Models [PDF]

open access: yesarXiv
Digital versions of real-world text documents often suffer from issues like environmental corrosion of the original document, low-quality scanning, or human interference. Existing document restoration and inpainting methods typically struggle with generalizing to unseen document styles and handling high-resolution images.
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Study on the characteristics and mechanism of antibiotic pollution in different aquifers

open access: yesShuiwen dizhi gongcheng dizhi
The risk posed by antibiotics in various aquifers has attracted wide attention. This study investigated the pollution characteristics and controlling factors of antibiotics in different types of aquifers, and identified the indicator factors of ...
Jialin WANG, Jinwei PAN, Fei LIU
doaj   +1 more source

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