Results 71 to 80 of about 2,583,085 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Falsification View of Success Typing

open access: yes, 2015
Dynamic languages are praised for their flexibility and expressiveness, but static analysis often yields many false positives and verification is cumbersome for lack of structure.
Jakob, Robert, Thiemann, Peter
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Duplicate Detection in the Reuters Collection [PDF]

open access: yes, 1997
While conducting some experiments with the Reuters collection, it was discovered that contained within it were a number of documents that were exact duplicates of each other (see Figure 1).
Sanderson, M.
core   +1 more source

Assembling and enriching digital library collections [PDF]

open access: yes, 2003
People who create digital libraries need to gather together the raw material, add metadata as necessary, and design and build new collections. This paper sets out the requirements for these tasks and describes a new tool that supports them interactively,
Bainbridge, David   +2 more
core   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ilex crenata 'Helleri' Helleri Holly

open access: yesEDIS, 2007
This document provides an overview of the dwarf Japanese holly (Ilex crenata ‘Helleri’), highlighting its characteristics, uses, and cultivation requirements.
Edward Gilman
doaj   +1 more source

Evaluation of an Internet Document Delivery Service [PDF]

open access: yes, 2001
An Internet-based Document Delivery Service (DDS) has been developed within the framework of the CNR ( the Italian Research National Council) Project BiblioMIME, in order to take advantage of new Internet technologies and promote cooperation among ...
Abba, Laura   +4 more
core  

An evaluation of Bradfordizing effects [PDF]

open access: yes, 2008
The purpose of this paper is to apply and evaluate the bibliometric method Bradfordizing for information retrieval (IR) experiments. Bradfordizing is used for generating core document sets for subject-specific questions and to reorder result sets from ...
Bates Marcia J.   +23 more
core   +8 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy