Results 31 to 40 of about 51,461 (259)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
International Journal of Networked and Distributed Computing (IJNDC), 2019 To provide affordable context recognition for general households, this paper presents a novel technique that integrate image-based cognitive Application Program Interface (API) and light-weight machine learning. Our key idea is to regard every image as a
Sinan Chen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Технологія та конструювання в електронній апаратурі, 2007 An approach to preparing printed circuit board drawings is proposed, which significantly simplifies documentation and streamlines document workflow. This method is intended for use in environments of automated design and production preparation.
A. A. Efimenko +2 more
doaj
SegClarity: An Attribution-Based XAI Workflow for Evaluating Historical Document Layout Models
Journal of ImagingIn recent years, deep learning networks have demonstrated remarkable progress in the semantic segmentation of historical documents. Nonetheless, their limited explainability remains a critical concern, as these models frequently operate as black boxes ...
Iheb Brini +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Proceedings of the International Conference on Applied Innovations in ITRailway freight transportation is a crucial component of global logistics, requiring efficient and secure document workflow management. Traditional document processing methods are often time-consuming, error-prone, and inefficient.
Mahamadaziz Rasulmukhamedov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Merging Hierarchically-Structured Documents in Workflow Systems
Electronic Notes in Theoretical Computer Science, 2008 AbstractWe consider the manipulation of hierarchically-structured documents within a complex workflow system. Such a system may consist of several subsystems distributed over a computer network. These subsystems can concurrently update partial views of the document.
Éric Badouel, Maurice Tchoupé Tchendji
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source