Results 61 to 70 of about 808,168 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

La Frase Quincenal en el Centro Documental de la Memoria Histórica: propaganda e ideología durante el Primer Franquismo

open access: yesSegle XX, 2019
Entre 1940 y 1951 la Delegación Provincial de Educación Popular de Barcelona de FET y de las JONS editó La Frase Quincenal, un conjunto de carteles que contienen consignas y motivos gráficos alusivos.
José Luis Hernández Luis, Centro Documental de la Memoria Histórica (Salamanca)
doaj  

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

A preservação documental no Arquivo Geral e no Arquivo Histórico Municipal da Prefeitura Municipal de Santa Maria [PDF]

open access: yes, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração.A pesquisa aqui descrita, caracterizada como um estudo de caso, investigou a preservação documental no Arquivo Geral e no ...
Silva, Beatriz Aita da
core  

La norma ISO 15489:2001 y su evolución hacia un cambio de estrategia en las organizaciones

open access: yesAcervo, 2015
Analisa a norma ISO 15489, suas características e perspectivas, bem como o modelo que propõe a implantação de um sistema de gestão de documentos nas organizações, sua relação com os sistemas de qualidade e a mudança de estratégia acarretada pelo ...
Joaquim Llansó Sanjuan
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Documental dramatizado “educando” [PDF]

open access: yes, 2011
La educación en Ecuador está en crisis, debido a falta de ofertas educativas, altos índices de deserción escolar; profesores mal pagados y desmotivados, poca y deficiente inversión, inestabilidad política: todos estos elementos han deteriorado la ...
Fernández Panta, María José   +1 more
core  

Volver a filmar: un abordaje del ‘documental del retorno’ a través del caso de Desembarcos (un taller en Buenos Aires) de Jeanine Meerapfe

open access: yesFotocinema: Revista Científica de Cine y Fotografía, 2017
Hacia el final de la última dictadura militar argentina (1976-1983), distintos documentalistas exiliados –o que residían en el exterior- retornaron a su país a filmar.
Paola Margulis
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Dos generaciones en busca del sentido: lecturas del documental Nietos (identidad y memoria) [PDF]

open access: yes, 2019
En el presente artículo nos proponemos analizar el documental Nietos (identidad y memoria) (Benjamín Ávila, 2004), que se centra en los procesos de construcción de memorias y reelaboración subjetiva de los jóvenes apropiados/as durante la última ...
Laino Sanchís, Fabricio Andrés
core   +1 more source

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