Results 101 to 110 of about 394,933 (283)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Colour adjustment: race and representation in post-apartheid South African documentary [PDF]

open access: yes, 2009
Includes abstract.Includes bibliographical references (p. 251-267).The goal of this dissertation is to examine the process of racial transformation within South Africa's documentary film industry and to assess how the nation's shifting identity is both ...
Pichaske, Kristin
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

INTERACTIVE DOCUMENTARY: DOCUMENTARY AND VIRTUALITY [PDF]

open access: yesThe Art and Science of Television, 2019
openaire   +1 more source

Documentary-for-the-Other: Relationships, Ethics and (Observational) Documentary

open access: yes, 2011
While documentary ethics has been largely normative to date, there is growing interest in alternative forms of ethical thinking. The work of Emmanuel Levinas in particular is providing a way of thinking through both the ethics of documentary viewing and ...
Nash, K (15530546)
core  

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Cognitive theory and documentary film

open access: yes, 2018
'Cognitive Theory and Documentary Film' is an edited collection of essays exploring the intersection between cognitive and documentary film studies. Given that most Western societies are mass-mediated cultures in which their citizens largely understand ...
Kramer, Mette   +2 more
core   +3 more sources

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