Results 51 to 60 of about 11,371 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Invest to Save: Report and Recommendations of the NSF-DELOS Working Group on Digital Archiving and Preservation [PDF]

open access: yes, 2003
Digital archiving and preservation are important areas for research and development, but there is no agreed upon set of priorities or coherent plan for research in this area.
Hedstrom, M.   +9 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

The Work Programme: a new public governance policy or a continuation of new public management? [PDF]

open access: yes, 2013
Since the 1970s, the governance of labour market policies in the UK has been characterised by New Public Management (NPM) traits and since the late 1990s the welfare system has experienced a trend towards activation.
Fuertes, Vanesa, McQuaid, Ronald
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

¿Es posible una gestión humana no funcionalista? Descripción de un modelo estratégico de gestión de personal

open access: yesUniversidad y Empresa, 2010
This paper describes a human management model as conceived in organizations that carry out a strategic direction of staff, based on a critical look of traditional management and some of its notions, such as the classical perspective of strategic ...
Héctor Bermúdez Restrepo
doaj  

Using documentary analysis to reveal narratives of mothering

open access: yes, 2002
This paper will outline a piece of research that did not aim primarily to use a narrative approach or to rely upon narrative inquiry. The initial focus of the research was concerned with using documentary analysis in order to investigate whether or ...
Kelly, Nancy
core  

Development of a risk management model for public-private partnerships in Uganda

open access: yes, 2023
Thesis (PhD)--Stellenbosch University, 2023.ENGLISH SUMMARY: Governments are collaborating with the private sector through public-private partnerships (PPPs) to address the public infrastructure funding gaps and inefficiencies associated with ...
Bagenda, Bonny
core  

Reconciliation responses, blame and expressions of guilt or shame [PDF]

open access: yes, 2013
Recipients of intergroup apologies have been found to prefer expressions of shame over guilt. However, there is little research comparing the responses of a wronged group with those of a blamed group.
Giner-Sorolla, Roger   +5 more
core   +1 more source

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