Results 161 to 170 of about 1,289,776 (315)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Mind the Gap! Documentation

, 2019
A series of photos to illustrate some of the processes outlined in the journal. The photos from the 2017 MTG! also illustrate the spirit of creative enquiry and collaboration in the room.
Foster, G.
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Documentation of Extended Focused Assessment with Sonography in Trauma (eFAST) Is Frequently Incomplete: A Prospective Observational Study. [PDF]

West J Emerg Med
Feuerherdt M, Elman MR, Hicks B, Sabbaj A, McLean WJ, Sreenivasan A, Gregory C, Gregory K, Schnittke N.   +8 more
europepmc   +1 more source

Bulletin de documentation française / Agence d'information et de documentation

, 1944
Variante(s) de titre : Agence d'information et de documentation, Bulletin de documentation ...
Agence d'information et de documentation (France). Auteur du texte
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Fiberoptic endoscopic evaluation of swallowing in German stroke units: a retrospective diagnosis-related group analysis (2019-2024). [PDF]

Neurol Res Pract
Ungerer MN, Bartig D, Agredo AM, Braun T, Gumbinger C.   +4 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Beyond Time Saved: Implementation, Equity, and the Utility Threshold for Nursing AI Scribes. [PDF]

J Med Internet Res
Ronquillo CE.
europepmc   +1 more source